DIS3-like exonuclease 2 (hDIS3L2) (EC 3.1.13.-)
1_MSHPD 6_ YRMNL 11_ RPLGT 16_ PRGVS 21_ AVAGP 26_ HDIGA 31_ SPGDK 36_ KSKNR 41_ STRGK 46_ KKSIF 51_ ETYMS 56_ KEDVS 61_ EGLKR 66_ GTLIQ 71_ GVLRI 76_ NPKKF 81_ HEAFI 86_ PSPDG 91_ DRDIF 96_ IDGVV 101_ ARNRA 106_ LNGDL 111_ VVVKL 116_ LPEEH 121_ WKVVK 126_ PESND 131_ KETEA 136_ AYESD 141_ IPEEL 146_ CGHHL 151_ PQQSL 156_ KSYND 161_ SPDVI 166_ VEAQF 171_ DGSDS 176_ EDGHG 181_ ITQNV 186_ LVDGV 191_ KKLSV 196_ CVSEK 201_ GREDG 206_ DAPVT 211_ KDETT 216_ CISQD 221_ TRALS 226_ EKSLQ 231_ RSAKV 236_ VYILE 241_ KKHSR 246_ AATGF 251_ LKLLA 256_ DKNSE 261_ LFRKY 266_ ALFSP 271_ SDHRV 276_ PRIYV 281_ PLKDC 286_ PQDFV 291_ ARPKD 296_ YANTL 301_ FICRI 306_ VDWKE 311_ DCNFA 316_ LGQLA 321_ KSLGQ 326_ AGEIE 331_ PETEG 336_ ILTEY 341_ GVDFS 346_ DFSSE 351_ VLECL 356_ PQGLP 361_ WTIPP 366_ EEFSK 371_ RRDLR 376_ KDCIF 381_ TIDPS 386_ TARDL 391_ DDALS 396_ CKPLA 401_ DGNFK 406_ VGVHI 411_ ADVSY 416_ FVPEG 421_ SDLDK 426_ VAAER 431_ ATSVY 436_ LVQKV 441_ VPMLP 446_ RLLCE 451_ ELCSL 456_ NPMSD 461_ KLTFS 466_ VIWTL 471_ TPEGK 476_ ILDEW 481_ FGRTI 486_ IRSCT 491_ KLSYE 496_ HAQSM 501_ IESPT 506_ EKIPA 511_ KELPP 516_ ISPEH 521_ SSEEV 526_ HQAVL 531_ NLHGI 536_ AKQLR 541_ QQRFV 546_ DGALR 551_ LDQLK 556_ LAFTL 561_ DHETG 566_ LPQGC 571_ HIYEY 576_ RESNK 581_ LVEEF 586_ MLLAN 591_ MAVAH 596_ KIHRA 601_ FPEQA 606_ LLRRH 611_ PPPQT 616_ RMLSD 621_ LVEFC 626_ DQMGL 631_ PVDFS 636_ SAGAL 641_ NKSLT 646_ QTFGD 651_ DKYSL 656_ ARKEV 661_ LTNMC 666_ SRPMQ 671_ MALYF 676_ CSGLL 681_ QDPAQ 686_ FRHYA 691_ LNVPL 696_ YTHFT 701_ SPIRR 706_ FADVL 711_ VHRLL 716_ AAALG 721_ YRERL 726_ DMAPD 731_ TLQKQ 736_ ADHCN 741_ DRRMA 746_ SKRVQ 751_ ELSTS 756_ LFFAV 761_ LVKES 766_ GPLES 771_ EAMVM 776_ GILKQ 781_ AFDVL 786_ VLRYG 791_ VQKRI 796_ YCNAL 801_ ALRSH 806_ HFQKV 811_ GKKPE 816_ LTLVW 821_ EPEDM 826_ EQEPA 831_ QQVIT 836_ IFSLV 841_ EVVLQ 846_ AESTA 851_ LKYSA 856_ ILKRP 861_ GTQGH 866_ LGPEK 871_ EEEES 876_DGEPE
1: 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation