ATP-dependent RNA helicase SUPV3L1, mitochondrial (EC 3.6.4.13) (Suppressor of var1 3-like protein 1) (SUV3-like protein 1)
1_MSFSR 6_ ALLWA 11_ RLPAG 16_ RQAGH 21_ RAAIC 26_ SALRP 31_ HFGPF 36_ PGVLG 41_ QVSVL 46_ ATASS 51_ SASGG 56_ SKIPN 61_ TSLFV 66_ PLTVK 71_ PQGPS 76_ ADGDV 81_ GAELT 86_ RPLDK 91_ NEVKK 96_ VLDKF 101_ YKRKE 106_ IQKLG 111_ ADYGL 116_ DARLF 121_ HQAFI 126_ SFRNY 131_ IMQSH 136_ SLDVD 141_ IHIVL 146_ NDICF 151_ GAAHA 156_ DDLFP 161_ FFLRH 166_ AKQIF 171_ PVLDC 176_ KDDLR 181_ KISDL 186_ RIPPN 191_ WYPDA 196_ RAMQR 201_ KIIFH 206_ SGPTN 211_ SGKTY 216_ HAIQK 221_ YFSAK 226_ SGVYC 231_ GPLKL 236_ LAHEI 241_ FEKSN 246_ AAGVP 251_ CDLVT 256_ GEERV 261_ TVQPN 266_ GKQAS 271_ HVSCT 276_ VEMCS 281_ VTTPY 286_ EVAVI 291_ DEIQM 296_ IRDPA 301_ RGWAW 306_ TRALL 311_ GLCAE 316_ EVHLC 321_ GEPAA 326_ IDLVM 331_ ELMYT 336_ TGEEV 341_ EVRDY 346_ KRLTP 351_ ISVLD 356_ HALES 361_ LDNLR 366_ PGDCI 371_ VCFSK 376_ NDIYS 381_ VSRQI 386_ EIRGL 391_ ESAVI 396_ YGSLP 401_ PGTKL 406_ AQAKK 411_ FNDPN 416_ DPCKI 421_ LVATD 426_ AIGMG 431_ LNLSI 436_ RRIIF 441_ YSLIK 446_ PSINE 451_ KGERE 456_ LEPIT 461_ TSQAL 466_ QIAGR 471_ AGRFS 476_ SRFKE 481_ GEVTT 486_ MNHED 491_ LSLLK 496_ EILKR 501_ PVDPI 506_ RAAGL 511_ HPTAE 516_ QIEMF 521_ AYHLP 526_ DATLS 531_ NLIDI 536_ FVDFS 541_ QVDGQ 546_ YFVCN 551_ MDDFK 556_ FSAEL 561_ IQHIP 566_ LSLRV 571_ RYVFC 576_ TAPIN 581_ KKQPF 586_ VCSSL 591_ LQFAR 596_ QYSRN 601_ EPLTF 606_ AWLRR 611_ YIKWP 616_ LLPPK 621_ NIKDL 626_ MDLEA 631_ VHDVL 636_ DLYLW 641_ LSYRF 646_ MDMFP 651_ DASLI 656_ RDLQK 661_ ELDGI 666_ IQDGV 671_ HNITK 676_ LIKMS 681_ ETHKL 686_ LNLEG 691_ FPSGS 696_ QSRLS 701_ GTLKS 706_ QARRT 711_ RGTKA 716_ LGSKA 721_ TEPPS 726_ PDAGE 731_ LSLAS 736_ RLVQQ 741_ GLLTP 746_ DMLKQ 751_ LEKEW 756_ MTQQT 761_ EHNKE 766_ KTESG 771_ THPKG 776_ TRRKK 781_KEPDS
1: Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Involved in the degradation of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules (PubMed:29967381). ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA