Eukaryotic peptide chain release factor GTP-binding subunit ERF3B (Eukaryotic peptide chain release factor subunit 3b) (eRF3b) (G1 to S phase transition protein 2 homolog)
1_MDSGS 6_ SSSDS 11_ APDCW 16_ DQVDM 21_ ESPGS 26_ APSGD 31_ GVSSA 36_ VAEAQ 41_ REPLS 46_ SAFSR 51_ KLNVN 56_ AKPFV 61_ PNVHA 66_ AEFVP 71_ SFLRG 76_ PTQPP 81_ TLPAG 86_ SGSND 91_ ETCTG 96_ AGYPQ 101_ GKRMG 106_ RGAPV 111_ EPSRE 116_ EPLVS 121_ LEGSN 126_ SAVTM 131_ ELSEP 136_ VVENG 141_ EVEMA 146_ LEESW 151_ EHSKE 156_ VSEAE 161_ PGGGS 166_ SGDSG 171_ PPEES 176_ GQEMM 181_ EEKEE 186_ IRKSK 191_ SVIVP 196_ SGAPK 201_ KEHVN 206_ VVFIG 211_ HVDAG 216_ KSTIG 221_ GQIMF 226_ LTGMV 231_ DKRTL 236_ EKYER 241_ EAKEK 246_ NRETW 251_ YLSWA 256_ LDTNQ 261_ EERDK 266_ GKTVE 271_ VGRAY 276_ FETER 281_ KHFTI 286_ LDAPG 291_ HKSFV 296_ PNMIG 301_ GASQA 306_ DLAVL 311_ VISAR 316_ KGEFE 321_ TGFEK 326_ GGQTR 331_ EHAML 336_ AKTAG 341_ VKHLI 346_ VLINK 351_ MDDPT 356_ VNWSI 361_ ERYEE 366_ CKEKL 371_ VPFLK 376_ KVGFS 381_ PKKDI 386_ HFMPC 391_ SGLTG 396_ ANIKE 401_ QSDFC 406_ PWYTG 411_ LPFIP 416_ YLDNL 421_ PNFNR 426_ SIDGP 431_ IRLPI 436_ VDKYK 441_ DMGTV 446_ VLGKL 451_ ESGSI 456_ FKGQQ 461_ LVMMP 466_ NKHNV 471_ EVLGI 476_ LSDDT 481_ ETDFV 486_ APGEN 491_ LKIRL 496_ KGIEE 501_ EEILP 506_ GFILC 511_ DPSNL 516_ CHSGR 521_ TFDVQ 526_ IVIIE 531_ HKSII 536_ CPGYN 541_ AVLHI 546_ HTCIE 551_ EVEIT 556_ ALISL 561_ VDKKS 566_ GEKSK 571_ TRPRF 576_ VKQDQ 581_ VCIAR 586_ LRTAG 591_ TICLE 596_ TFKDF 601_ PQMGR 606_ FTLRD 611_ EGKTI 616_ AIGKV 621_LKLVP
1: GTPase component of the eRF1-eRF3-GTP ternary complex, a ternary complex that mediates translation termination in response to the termination codons UAA, UAG and UGA (PubMed:11524954, PubMed:15987998, PubMed:17562865). GSPT2/ERF3B mediates ETF1/ERF1 delivery to stop codons: The eRF1-eRF3-GTP complex binds to a stop codon in the ribosomal A-site (PubMed:15987998). GTP hydrolysis by GSPT2/ERF3B induces a conformational change that leads to its dissociation, permitting ETF1/ERF1 to accommodate fully in the A-site (PubMed:15987998). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (PubMed:19417104)