Fanconi anemia group M protein (Protein FACM) (EC 3.6.4.13) (ATP-dependent RNA helicase FANCM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog)
1_MSGRQ 6_ RTLFQ 11_ TWGSS 16_ ISRSS 21_ GTPGC 26_ SSGTE 31_ RPQSP 36_ GSSKA 41_ PLPAA 46_ AEAQL 51_ ESDDD 56_ VLLVA 61_ AYEAE 66_ RQLCL 71_ ENGGF 76_ CTSAG 81_ ALWIY 86_ PTNCP 91_ VRDYQ 96_ LHISR 101_ AALFC 106_ NTLVC 111_ LPTGL 116_ GKTFI 121_ AAVVM 126_ YNFYR 131_ WFPSG 136_ KVVFM 141_ APTKP 146_ LVTQQ 151_ IEACY 156_ QVMGI 161_ PQSHM 166_ AEMTG 171_ STQAS 176_ TRKEI 181_ WCSKR 186_ VLFLT 191_ PQVMV 196_ NDLSR 201_ GACPA 206_ AEIKC 211_ LVIDE 216_ AHKAL 221_ GNYAY 226_ CQVVR 231_ ELVKY 236_ TNHFR 241_ ILALS 246_ ATPGS 251_ DIKAV 256_ QQVIT 261_ NLLIG 266_ QIELR 271_ SEDSP 276_ DILTY 281_ SHERK 286_ VEKLI 291_ VPLGE 296_ ELAAI 301_ QKTYI 306_ QILES 311_ FARSL 316_ IQRNV 321_ LMRRD 326_ IPNLT 331_ KYQII 336_ LARDQ 341_ FRKNP 346_ SPNIV 351_ GIQQG 356_ IIEGE 361_ FAICI 366_ SLYHG 371_ YELLQ 376_ QMGMR 381_ SLYFF 386_ LCGIM 391_ DGTKG 396_ MTRSK 401_ NELGR 406_ NEDFM 411_ KLYNH 416_ LECMF 421_ ARTRS 426_ TSANG 431_ ISAIQ 436_ QGDKN 441_ KKFVY 446_ SHPKL 451_ KKLEE 456_ VVIEH 461_ FKSWN 466_ AENTT 471_ EKKRD 476_ ETRVM 481_ IFSSF 486_ RDSVQ 491_ EIAEM 496_ LSQHQ 501_ PIIRV 506_ MTFVG 511_ HASGK 516_ STKGF 521_ TQKEQ 526_ LEVVK 531_ QFRDG 536_ GYNTL 541_ VSTCV 546_ GEEGL 551_ DIGEV 556_ DLIIC 561_ FDSQK 566_ SPIRL 571_ VQRMG 576_ RTGRK 581_ RQGRI 586_ VIILS 591_ EGREE 596_ RIYNQ 601_ SQSNK 606_ RSIYK 611_ AISSN 616_ RQVLH 621_ FYQRS 626_ PRMVP 631_ DGINP 636_ KLHKM 641_ FITHG 646_ VYEPE 651_ KPSRN 656_ LQRKS 661_ SIFSY 666_ RDGMR 671_ QSSLK 676_ KDWFL 681_ SEEEF 686_ KLWNR 691_ LYRLR 696_ DSDEI 701_ KEITL 706_ PQVQF 711_ SSLQN 716_ EENKP 721_ AQEST 726_ TGIHQ 731_ LSLSE 736_ WRLWQ 741_ DHPLP 746_ THQVD 751_ HSDRC 756_ RHFIG 761_ LMQMI 766_ EGMRH 771_ EEGEC 776_ SYELE 781_ VESYL 786_ QMEDV 791_ TSTFI 796_ APRNE 801_ SNNLA 806_ SDTFI 811_ THKKS 816_ SFIKN 821_ INQGS 826_ SSSVI 831_ ESDEE 836_ CAEIV 841_ KQTHI 846_ KPTKI 851_ VSLKK 856_ KVSKE 861_ IKKDQ 866_ LKKEN 871_ NHGII 876_ DSVDN 881_ DRNST 886_ VENIF 891_ QEDLP 896_ NDKRT 901_ SDTDE 906_ IAATC 911_ TINEN 916_ VIKEP 921_ CVLLT 926_ ECQFT 931_ NKSTS 936_ SLAGN 941_ VLDSG 946_ YNSFN 951_ DEKSV 956_ SSNLF 961_ LPFEE 966_ ELYIV 971_ RTDDQ 976_ FYNCH 981_ SLTKE 986_ VLANV 991_ ERFLS 996_ YSPPP 1001_ LSGLS 1006_ DLEYE 1011_ IAKGT 1016_ ALENL 1021_ LFLPC 1026_ AEHLR 1031_ SDKCT 1036_ CLLSH 1041_ SAVNS 1046_ QQNLE 1051_ LNSLK 1056_ CINYP 1061_ SEKSC 1066_ LYDIP 1071_ NDNIS 1076_ DEPSL 1081_ CDCDV 1086_ HKHNQ 1091_ NENLV 1096_ PNNRV 1101_ QIHRS 1106_ PAQNL 1111_ VGENN 1116_ HDVDN 1121_ SDLPV 1126_ LSTDQ 1131_ DESLL 1136_ LFEDV 1141_ NTEFD 1146_ DVSLS 1151_ PLNSK 1156_ SESLP 1161_ VSDKT 1166_ AISET 1171_ PLVSQ 1176_ FLISD 1181_ ELLLD 1186_ NNSEL 1191_ QDQIT 1196_ RDANS 1201_ FKSRD 1206_ QRGVQ 1211_ EEKVK 1216_ NHEDI 1221_ FDCSR 1226_ DLFSV 1231_ TFDLG 1236_ FCSPD 1241_ SDDEI 1246_ LEHTS 1251_ DSNRP 1256_ LDDLY 1261_ GRYLE 1266_ IKEIS 1271_ DANYV 1276_ SNQAL 1281_ IPRDH 1286_ SKNFT 1291_ SGTVI 1296_ IPSNE 1301_ DMQNP 1306_ NYVHL 1311_ PLSAA 1316_ KNEEL 1321_ LSPGY 1326_ SQFSL 1331_ PVQKK 1336_ VMSTP 1341_ LSKSN 1346_ TLNSF 1351_ SKIRK 1356_ EILKT 1361_ PDSSK 1366_ EKVNL 1371_ QRFKE 1376_ ALNST 1381_ FDYSE 1386_ FSLEK 1391_ SKSSG 1396_ PMYLH 1401_ KSCHS 1406_ VEDGQ 1411_ LLTSN 1416_ ESEDD 1421_ EIFRR 1426_ KVKRA 1431_ KGNVL 1436_ NSPED 1441_ QKNSE 1446_ VDSPL 1451_ HAVKK 1456_ RRFPI 1461_ NRSEL 1466_ SSSDE 1471_ SENFP 1476_ KPCSQ 1481_ LEDFK 1486_ VCNGN 1491_ ARRGI 1496_ KVPKR 1501_ QSHLK 1506_ HVARK 1511_ FLDDE 1516_ AELSE 1521_ EDAEY 1526_ VSSDE 1531_ NDESE 1536_ NEQDS 1541_ SLLDF 1546_ LNDET 1551_ QLSQA 1556_ INDSE 1561_ MRAIY 1566_ MKSLR 1571_ SPMMN 1576_ NKYKM 1581_ IHKTH 1586_ KNINI 1591_ FSQIP 1596_ EQDET 1601_ YLEDS 1606_ FCVDE 1611_ EESCK 1616_ GQSSE 1621_ EEVCV 1626_ DFNLI 1631_ TDDCF 1636_ ANSKK 1641_ YKTRR 1646_ AVMLK 1651_ EMMEQ 1656_ NCAHS 1661_ KKKLS 1666_ RIILP 1671_ DDSSE 1676_ EENNV 1681_ NDKRE 1686_ SNIAV 1691_ NPSTV 1696_ KKNKQ 1701_ QDHCL 1706_ NSVPS 1711_ GSSAQ 1716_ SKVRS 1721_ TPRVN 1726_ PLAKQ 1731_ SKQTS 1736_ LNLKD 1741_ TISEV 1746_ SDFKP 1751_ QNHNE 1756_ VQSTT 1761_ PPFTT 1766_ VDSQK 1771_ DCRKF 1776_ PVPQK 1781_ DGSAL 1786_ EDSST 1791_ SGASC 1796_ SKSRP 1801_ HLAGT 1806_ HTSLR 1811_ LPQEG 1816_ KGTCI 1821_ LVGGH 1826_ EITSG 1831_ LEVIS 1836_ SLRAI 1841_ HGLQV 1846_ EVCPL 1851_ NGCDY 1856_ IVSNR 1861_ MVVER 1866_ RSQSE 1871_ MLNSV 1876_ NKNKF 1881_ IEQIQ 1886_ HLQSM 1891_ FERIC 1896_ VIVEK 1901_ DREKT 1906_ GDTSR 1911_ MFRRT 1916_ KSYDS 1921_ LLTTL 1926_ IGAGI 1931_ RILFS 1936_ SCQEE 1941_ TADLL 1946_ KELSL 1951_ VEQRK 1956_ NVGIH 1961_ VPTVV 1966_ NSNKS 1971_ EALQF 1976_ YLSIP 1981_ NISYI 1986_ TALNM 1991_ CHQFS 1996_ SVKRM 2001_ ANSSL 2006_ QEISM 2011_ YAQVT 2016_ HQKAE 2021_ EIYRY 2026_ IHYVF 2031_ DIQML 2036_ PNDLN 2041_QDRLK
1: DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (PubMed:16116422). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:16116422, PubMed:19423727, PubMed:20347428, PubMed:20347429, PubMed:29231814). In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (PubMed:20347428, PubMed:20347429). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX (PubMed:20347429). In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates (PubMed:17289582). In vitro, on its own, strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA (PubMed:16116434)