Gene name: SHLD1

Uniprot entry:

Q8IYI0

Protein names:

Shieldin complex subunit 1 (RINN1-REV7-interacting novel NHEJ regulator 3) (Shield complex subunit 1)

Protein sequence:

1_MAARD 6_ ATSGS 11_ LSEES 16_ SALDL 21_ PSACD 26_ IRDYV 31_ LQGPS 36_ QEANS 41_ EAFSS 46_ LEFHS 51_ FPYSS 56_ DVDPD 61_ TSNLN 66_ IEQNN 71_ SWTAE 76_ NFWLD 81_ PAVKG 86_ QSEKE 91_ EDDGL 96_ RKSLD 101_ RFYEM 106_ FGHPQ 111_ PGSAN 116_ SLSAS 121_ VCKCL 126_ SQKIT 131_ QLRGQ 136_ ESQKY 141_ ALRSF 146_ QMARV 151_ IFNRD 156_ GCSVL 161_ QRHSR 166_ DTHFY 171_ PLEEG 176_ STSLD 181_ DEKPN 186_ PGLSK 191_ DITHF 196_LLQQN

Protein annotations

Protein functions:

1: Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres