Septin-12
1_MDPLR 6_ RSPSP 11_ CLSSQ 16_ PSSPS 21_ TPPCE 26_ MLGPV 31_ GIEAV 36_ LDQLK 41_ IKAMK 46_ MGFEF 51_ NIMVV 56_ GQSGL 61_ GKSTM 66_ VNTLF 71_ KSKVW 76_ KSNPP 81_ GLGVP 86_ TPQTL 91_ QLHSL 96_ THVIE 101_ EKGVK 106_ LKLTV 111_ TDTPG 116_ FGDQI 121_ NNDNC 126_ WDPIL 131_ GYINE 136_ QYEQY 141_ LQEEI 146_ LITRQ 151_ RHIPD 156_ TRVHC 161_ CVYFV 166_ PPTGH 171_ CLRPL 176_ DIEFL 181_ QRLCR 186_ TVNVV 191_ PVIAR 196_ ADSLT 201_ MEERE 206_ AFRRR 211_ IQQNL 216_ RTHCI 221_ DVYPQ 226_ MCFDE 231_ DINDK 236_ ILNSK 241_ LRDRI 246_ PFAVV 251_ GADQE 256_ HLVNG 261_ RCVLG 266_ RKTKW 271_ GIIEV 276_ ENMAH 281_ CEFPL 286_ LRDLL 291_ IRSHL 296_ QDLKD 301_ ITHNI 306_ HYENY 311_ RVIRL 316_ NESHL 321_ LPRGP 326_ GWVNL 331_ APASP 336_ GQLTT 341_ PRTFK 346_ VCRGA 351_HDDSD
1: Filament-forming cytoskeletal GTPase (By similarity). Involved in spermatogenesis. Involved in the morphogenesis of sperm heads and the elongation of sperm tails probably implicating the association with alpha- and beta-tubulins (PubMed:24213608). Forms a filamentous structure with SEPTIN7, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). May play a role in cytokinesis (Potential)