Ribonuclease SLFN12 (EC 3.1.-.-) (Schlafen family member 12)
1_MNISV 6_ DLETN 11_ YAELV 16_ LDVGR 21_ VTLGE 26_ NSRKK 31_ MKDCK 36_ LRKKQ 41_ NESVS 46_ RAMCA 51_ LLNSG 56_ GGVIK 61_ AEIEN 66_ EDYSY 71_ TKDGI 76_ GLDLE 81_ NSFSN 86_ ILLFV 91_ PEYLD 96_ FMQNG 101_ NYFLI 106_ FVKSW 111_ SLNTS 116_ GLRIT 121_ TLSSN 126_ LYKRD 131_ ITSAK 136_ VMNAT 141_ AALEF 146_ LKDMK 151_ KTRGR 156_ LYLRP 161_ ELLAK 166_ RPCVD 171_ IQEEN 176_ NMKAL 181_ AGVFF 186_ DRTEL 191_ DRKEK 196_ LTFTE 201_ STHVE 206_ IKNFS 211_ TEKLL 216_ QRIKE 221_ ILPQY 226_ VSAFA 231_ NTDGG 236_ YLFIG 241_ LNEDK 246_ EIIGF 251_ KAEMS 256_ DLDDL 261_ EREIE 266_ KSIRK 271_ MPVHH 276_ FCMEK 281_ KKINY 286_ SCKFL 291_ GVYDK 296_ GSLCG 301_ YVCAL 306_ RVERF 311_ CCAVF 316_ AKEPD 321_ SWHVK 326_ DNRVM 331_ QLTRK 336_ EWIQF 341_ MVEAE 346_ PKFSS 351_ SYEEV 356_ ISQIN 361_ TSLPA 366_ PHSWP 371_ LLEWQ 376_ RQRHH 381_ CPGLS 386_ GRITY 391_ TPENL 396_ CRKLF 401_ LQHEG 406_ LKQLI 411_ CEEMD 416_ SVRKG 421_ SLIFS 426_ RSWSV 431_ DLGLQ 436_ ENHKV 441_ LCDAL 446_ LISQD 451_ SPPVL 456_ YTFHM 461_ VQDEE 466_ FKGYS 471_ TQTAL 476_ TLKQK 481_ LAKIG 486_ GYTKK 491_ VCVMT 496_ KIFYL 501_ SPEGM 506_ TSCQY 511_ DLRSQ 516_ VIYPE 521_ SYYFT 526_ RRKYL 531_ LKALF 536_ KALKR 541_ LKSLR 546_ DQFSF 551_ AENLY 556_ QIIGI 561_ DCFQK 566_ NDKKM 571_FKSCR
1: Ribonuclease which is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling (PubMed:31420216, PubMed:34272366, PubMed:34707099, PubMed:35104454). May play a role in cell differentiation (PubMed:30045019)