E3 ubiquitin-protein ligase TRIM22 (EC 2.3.2.27) (50 kDa-stimulated trans-acting factor) (RING finger protein 94) (RING-type E3 ubiquitin transferase TRIM22) (Staf-50) (Tripartite motif-containing protein 22)
1_MDFSV 6_ KVDIE 11_ KEVTC 16_ PICLE 21_ LLTEP 26_ LSLDC 31_ GHSFC 36_ QACIT 41_ AKIKE 46_ SVIIS 51_ RGESS 56_ CPVCQ 61_ TRFQP 66_ GNLRP 71_ NRHLA 76_ NIVER 81_ VKEVK 86_ MSPQE 91_ GQKRD 96_ VCEHH 101_ GKKLQ 106_ IFCKE 111_ DGKVI 116_ CWVCE 121_ LSQEH 126_ QGHQT 131_ FRINE 136_ VVKEC 141_ QEKLQ 146_ VALQR 151_ LIKED 156_ QEAEK 161_ LEDDI 166_ RQERT 171_ AWKNY 176_ IQIER 181_ QKILK 186_ GFNEM 191_ RVILD 196_ NEEQR 201_ ELQKL 206_ EEGEV 211_ NVLDN 216_ LAAAT 221_ DQLVQ 226_ QRQDA 231_ STLIS 236_ DLQRR 241_ LRGSS 246_ VEMLQ 251_ DVIDV 256_ MKRSE 261_ SWTLK 266_ KPKSV 271_ SKKLK 276_ SVFRV 281_ PDLSG 286_ MLQVL 291_ KELTD 296_ VQYYW 301_ VDVML 306_ NPGSA 311_ TSNVA 316_ ISVDQ 321_ RQVKT 326_ VRTCT 331_ FKNSN 336_ PCDFS 341_ AFGVF 346_ GCQYF 351_ SSGKY 356_ YWEVD 361_ VSGKI 366_ AWILG 371_ VHSKI 376_ SSLNK 381_ RKSSG 386_ FAFDP 391_ SVNYS 396_ KVYSR 401_ YRPQY 406_ GYWVI 411_ GLQNT 416_ CEYNA 421_ FEDSS 426_ SSDPK 431_ VLTLF 436_ MAVPP 441_ CRIGV 446_ FLDYE 451_ AGIVS 456_ FFNVT 461_ NHGAL 466_ IYKFS 471_ GCRFS 476_ RPAYP 481_ YFNPW 486_ NCLVP 491_MTVCP
1: Interferon-induced E3 ubiquitin ligase that plays important roles in innate and adaptive immunity (PubMed:25683609, PubMed:35777501). Restricts the replication of many viruses including HIV-1, encephalomyocarditis virus (EMCV), hepatitis B virus (HBV), hepatitis C virus (HCV) or Zika virus (ZIKV) (PubMed:25683609, PubMed:35777501, PubMed:36042495). Mechanistically, negatively regulates HCV replication by promoting ubiquitination and subsequent degradation of viral NS5A (PubMed:25683609). Also acts by promoting the degradation of Zika virus NS1 and NS3 proteins through proteasomal degradation (PubMed:36042495). Acts as a suppressor of basal HIV-1 LTR-driven transcription by preventing Sp1 binding to the HIV-1 promoter (PubMed:26683615). Also plays a role in antiviral immunity by co-regulating together with NT5C2 the RIGI/NF-kappa-B pathway by promoting 'Lys-63'-linked ubiquitination of RIGI, while NT5C2 is responsible for 'Lys-48'-linked ubiquitination of RIGI (PubMed:36159777). Participates in adaptive immunity by suppressing the amount of MHC class II protein in a negative feedback manner in order to limit the extent of MHC class II induction (PubMed:35777501)