SET and MYND domain-containing protein 4 (EC 2.1.1.-)
1_MDLPV 6_ DEWKS 11_ YLLQK 16_ WASLP 21_ TSVQV 26_ TISTA 31_ ETLRD 36_ IFLHS 41_ SSLLQ 46_ PEDEL 51_ FLKRL 56_ SKGYL 61_ VGKDS 66_ DAPLF 71_ YREEG 76_ NKKFQ 81_ EKDYT 86_ GAAVL 91_ YSKGV 96_ SHSRP 101_ NTEDM 106_ SLCHA 111_ NRSAA 116_ LFHLG 121_ QYETC 126_ LKDIN 131_ RAQTH 136_ GYPER 141_ LQPKI 146_ MLRKA 151_ ECLVA 156_ LGRLQ 161_ EASQT 166_ ISDLE 171_ RNFTA 176_ TPALA 181_ DVLPQ 186_ TLQRN 191_ LHRLK 196_ MKMQE 201_ KDSLT 206_ ESFPA 211_ ALAKT 216_ LEDAA 221_ LREEN 226_ EQLSN 231_ ASSSI 236_ GLCVD 241_ PLKGR 246_ CLVAT 251_ KDILP 256_ GELLV 261_ QEDAF 266_ VSVLN 271_ PGELP 276_ PPHHG 281_ LDSKW 286_ DTRVT 291_ NGDLY 296_ CHRCL 301_ KHTLA 306_ TVPCD 311_ GCSYA 316_ KYCSQ 321_ ECLQQ 326_ AWELY 331_ HRTEC 336_ PLGGL 341_ LLTLG 346_ VFCHI 351_ ALRLT 356_ LLVGF 361_ EDVRK 366_ IITKL 371_ CDKIS 376_ NKDIC 381_ LPESN 386_ NQVKT 391_ LNYGL 396_ GESEK 401_ NGNIV 406_ ETPIP 411_ GCDIN 416_ GKYEN 421_ NYNAV 426_ FNLLP 431_ HTENH 436_ SPEHK 441_ FLCAL 446_ CVSAL 451_ CRQLE 456_ AASLQ 461_ AIPTE 466_ RIVNS 471_ SQLKA 476_ AVTPE 481_ LCPDV 486_ TIWGV 491_ AMLRH 496_ MLQLQ 501_ CNAQA 506_ MTTIQ 511_ HTGPK 516_ GSIVT 521_ DSRQV 526_ RLATG 531_ IFPVI 536_ SLLNH 541_ SCSPN 546_ TSVSF 551_ ISTVA 556_ TIRAS 561_ QRIRK 566_ GQEIL 571_ HCYGP 576_ HKSRM 581_ GVAER 586_ QQKLR 591_ SQYFF 596_ DCACP 601_ ACQTE 606_ AHRMA 611_ AGPRW 616_ EAFCC 621_ NSCGA 626_ PMQGD 631_ DVLRC 636_ GSRSC 641_ AESAV 646_ SRDHL 651_ VSRLQ 656_ DLQQQ 661_ VRVAQ 666_ KLLRD 671_ GELER 676_ AVQRL 681_ SGCQR 686_ DAESF 691_ LWAEH 696_ AVVGE 701_ IADGL 706_ ARACA 711_ ALGDW 716_ QKSAT 721_ HLQRS 726_ LYVVE 731_ VRHGP 736_ SSVEM 741_ GHELF 746_ KLAQI 751_ FFNGF 756_ AVPEA 761_ LSTIQ 766_ KAEEV 771_ LSLHC 776_ GPWDD 781_ EIQEL 786_ QKMKS 791_ CLLDL 796_PPTPV
1: Protein-lysine N-methyltransferase. Monomethylates PRMT5, modulating its transcriptional activity (PubMed:38438251). May also act as a histone methyltransferase (By similarity). Plays a critical role in cardiac development. Acts as a key epigenetic regulator of gene expression during cardiac development via its dual activities as a methyltransferase and negative regulator of HDAC1 (By similarity)