Tomoregulin-1 (TR-1) (H7365) (Transmembrane protein with EGF-like and one follistatin-like domain)
1_MGAAA 6_ AEAPL 11_ RLPAA 16_ PPLAF 21_ CCYTS 26_ VLLLF 31_ AFSLP 36_ GSRAS 41_ NQPPG 46_ GGGGS 51_ GGDCP 56_ GGKGK 61_ SINCS 66_ ELNVR 71_ ESDVR 76_ VCDES 81_ SCKYG 86_ GVCKE 91_ DGDGL 96_ KCACQ 101_ FQCHT 106_ NYIPV 111_ CGSNG 116_ DTYQN 121_ ECFLR 126_ RAACK 131_ HQKEI 136_ TVIAR 141_ GPCYS 146_ DNGSG 151_ SGEGE 156_ EEGSG 161_ AEVHR 166_ KHSKC 171_ GPCKY 176_ KAECD 181_ EDAEN 186_ VGCVC 191_ NIDCS 196_ GYSFN 201_ PVCAS 206_ DGSSY 211_ NNPCF 216_ VREAS 221_ CIKQE 226_ QIDIR 231_ HLGHC 236_ TDTDD 241_ TSLLG 246_ KKDDG 251_ LQYRP 256_ DVKDA 261_ SDQRE 266_ DVYIG 271_ NHMPC 276_ PENLN 281_ GYCIH 286_ GKCEF 291_ IYSTQ 296_ KASCR 301_ CESGY 306_ TGQHC 311_ EKTDF 316_ SILYV 321_ VPSRQ 326_ KLTHV 331_ LIAAI 336_ IGAVQ 341_ IAIIV 346_ AIVMC 351_ ITRKC 356_ PKNNR 361_ GRRQK 366_ QNLGH 371_FTSDT
1: Neuron-specific restriction factor that prevents herpes simplex virus 1 (HHV-1) infection in the brain by blocking viral entry (PubMed:39048823, PubMed:39048830). Also able to restrict herpes simplex virus 2 (HHV-2) infection, although to a lesser extent (PubMed:39048823). Acts by preventing the association between the viral glycoprotein D (gD) and its cell surface receptor NECTIN1, thereby inhibiting fusion of the virus and the cell membrane (PubMed:39048823, PubMed:39048830). Also able to prevent the association between the viral glycoprotein B (gB) and MYH9/NMMHC-IIA and MYH10/NMMHC-IIB receptors (PubMed:39048823). May be a tumor suppressor in brain cancers (PubMed:12743596)