Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2)
1_MEVVG 6_ DFEYS 11_ KRDLV 16_ GHGAF 21_ AVVFR 26_ GRHRQ 31_ KTDWE 36_ VAIKS 41_ INKKN 46_ LSKSQ 51_ ILLGK 56_ EIKIL 61_ KELQH 66_ ENIVA 71_ LYDVQ 76_ ELPNS 81_ VFLVM 86_ EYCNG 91_ GDLAD 96_ YLQAK 101_ GTLSE 106_ DTIRV 111_ FLHQI 116_ AAAMR 121_ ILHSK 126_ GIIHR 131_ DLKPQ 136_ NILLS 141_ YANRR 146_ KSSVS 151_ GIRIK 156_ IADFG 161_ FARYL 166_ HSNMM 171_ AATLC 176_ GSPMY 181_ MAPEV 186_ IMSQH 191_ YDAKA 196_ DLWSI 201_ GTVIY 206_ QCLVG 211_ KPPFQ 216_ ANSPQ 221_ DLRMF 226_ YEKNR 231_ SLMPS 236_ IPRET 241_ SPYLA 246_ NLLLG 251_ LLQRN 256_ QKDRM 261_ DFEAF 266_ FSHPF 271_ LEQGP 276_ VKKSC 281_ PVPVP 286_ MYSGS 291_ VSGSS 296_ CGSSP 301_ SCRFA 306_ SPPSL 311_ PDMQH 316_ IQEEN 321_ LSSPP 326_ LGPPN 331_ YLQVS 336_ KDSAS 341_ TSSKN 346_ SSCDT 351_ DDFVL 356_ VPHNI 361_ SSDHS 366_ CDMPV 371_ GTAGR 376_ RASNE 381_ FLVCG 386_ GQCQP 391_ TVSPH 396_ SETAP 401_ IPVPT 406_ QIRNY 411_ QRIEQ 416_ NLTST 421_ ASSGT 426_ NVHGS 431_ PRSAV 436_ VRRSN 441_ TSPMG 446_ FLRPG 451_ SCSPV 456_ PADTA 461_ QTVGR 466_ RLSTG 471_ SSRPY 476_ SPSPL 481_ VGTIP 486_ EQFSQ 491_ CCCGH 496_ PQGHD 501_ SRSRN 506_ SSGSP 511_ VPQAQ 516_ SPQSL 521_ LSGAR 526_ LQSAP 531_ TLTDI 536_ YQNKQ 541_ KLRKQ 546_ HSDPV 551_ CPSHT 556_ GAGYS 561_ YSPQP 566_ SRPGS 571_ LGTSP 576_ TKHLG 581_ SSPRS 586_ SDWFF 591_ KTPLP 596_ TIIGS 601_ PTKTT 606_ APFKI 611_ PKTQA 616_ SSNLL 621_ ALVTR 626_ HGPAE 631_ EQSKD 636_ GNEPR 641_ ECAHC 646_ LLVQG 651_ SERQR 656_ AEQQS 661_ KAVFG 666_ RSVST 671_ GKLSD 676_ QQGKT 681_ PICRH 686_ QGSTD 691_ SLNTE 696_ RPMDI 701_ APAGA 706_ CGGVL 711_ APPAG 716_ TAASS 721_ KAVLF 726_ TVGSP 731_ PHSAA 736_ APTCT 741_ HMFLR 746_ TRTTS 751_ VGPSN 756_ SGGSL 761_ CAMSG 766_ RVCVG 771_ SPPGP 776_ GFGSS 781_ PPGAE 786_ AAPSL 791_ RYVPY 796_ GASPP 801_ SLEGL 806_ ITFEA 811_ PELPE 816_ ETLME 821_ REHTD 826_ TLRHL 831_ NVMLM 836_ FTECV 841_ LDLTA 846_ MRGGN 851_ PELCT 856_ SAVSL 861_ YQIQE 866_ SVVVD 871_ QISQL 876_ SKDWG 881_ RVEQL 886_ VLYMK 891_ AAQLL 896_ AASLH 901_ LAKAQ 906_ IKSGK 911_ LSPST 916_ AVKQV 921_ VKNLN 926_ ERYKF 931_ CITMC 936_ KKLTE 941_ KLNRF 946_ FSDKQ 951_ RFIDE 956_ INSVT 961_ AEKLI 966_ YNCAV 971_ EMVQS 976_ AALDE 981_ MFQQT 986_ EDIVY 991_ RYHKA 996_ ALLLE 1001_ GLSRI 1006_ LQDPA 1011_ DIENV 1016_ HKYKC 1021_ SIERR 1026_ LSALC 1031_HSTAT
1: Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons