E3 ubiquitin-protein ligase HACE1 (EC 2.3.2.26) (HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1) (HECT-type E3 ubiquitin transferase HACE1)
1_MERAM 6_ EQLNR 11_ LTRSL 16_ RRART 21_ VELPE 26_ DNETA 31_ VYTLM 36_ PMVMA 41_ DQHRS 46_ VSELL 51_ SNSKF 56_ DVNYA 61_ FGRVK 66_ RSLLH 71_ IAANC 76_ GSVEC 81_ LVLLL 86_ KKGAN 91_ PNYQD 96_ ISGCT 101_ PLHLA 106_ ARNGQ 111_ KKCMS 116_ KLLEY 121_ SADVN 126_ ICNNE 131_ GLTAI 136_ HWLAV 141_ NGRTE 146_ LLHDL 151_ VQHVS 156_ DVDVE 161_ DAMGQ 166_ TALHV 171_ ACQNG 176_ HKTTV 181_ QCLLD 186_ SGADI 191_ NRPNV 196_ SGATP 201_ LYFAC 206_ SHGQR 211_ DTAQI 216_ LLLRG 221_ AKYLP 226_ DKNGV 231_ TPLDL 236_ CVQGG 241_ YGETC 246_ EVLIQ 251_ YHPRL 256_ FQTII 261_ QMTQN 266_ EDLRE 271_ NMLRQ 276_ VLEHL 281_ SQQSE 286_ SQYLK 291_ ILTSL 296_ AEVAT 301_ TNGHK 306_ LLSLS 311_ SNYDA 316_ QMKSL 321_ LRIVR 326_ MFCHV 331_ FRIGP 336_ SSPSN 341_ GIDMG 346_ YNGNK 351_ TPRSQ 356_ VFKPL 361_ ELLWH 366_ SLDEW 371_ LVLIA 376_ TELMK 381_ NKRDS 386_ TEITS 391_ ILLKQ 396_ KGQDQ 401_ DAASI 406_ PPFEP 411_ PGPGS 416_ YENLS 421_ TGTRE 426_ SKPDA 431_ LAGRQ 436_ EASAD 441_ CQDVI 446_ SMTAN 451_ RLSAV 456_ IQAFY 461_ MCCSC 466_ QMPPG 471_ MTSPR 476_ FIEFV 481_ CKHDE 486_ VLKCF 491_ VNRNP 496_ KIIFD 501_ HFHFL 506_ LECPE 511_ LMSRF 516_ MHIIK 521_ AQPFK 526_ DRCEW 531_ FYEHL 536_ HSGQP 541_ DSDMV 546_ HRPVN 551_ ENDIL 556_ LVHRD 561_ SIFRS 566_ SCEVV 571_ SKANC 576_ AKLKQ 581_ GIAVR 586_ FHGEE 591_ GMGQG 596_ VVREW 601_ FDILS 606_ NEIVN 611_ PDYAL 616_ FTQSA 621_ DGTTF 626_ QPNSN 631_ SYVNP 636_ DHLNY 641_ FRFAG 646_ QILGL 651_ ALNHR 656_ QLVNI 661_ YFTRS 666_ FYKHI 671_ LGIPV 676_ NYQDV 681_ ASIDP 686_ EYAKN 691_ LQWIL 696_ DNDIS 701_ DLGLE 706_ LTFSV 711_ ETDVF 716_ GAMEE 721_ VPLKP 726_ GGGSI 731_ LVTQN 736_ NKAEY 741_ VQLVT 746_ ELRMT 751_ RAIQP 756_ QINAF 761_ LQGFH 766_ MFIPP 771_ SLIQL 776_ FDEYE 781_ LELLL 786_ SGMPE 791_ IDVSD 796_ WIKNT 801_ EYTSG 806_ YERED 811_ PVIQW 816_ FWEVV 821_ EDITQ 826_ EERVL 831_ LLQFV 836_ TGSSR 841_ VPHGG 846_ FANIM 851_ GGSGL 856_ QNFTI 861_ AAVPY 866_ TPNLL 871_ PTSST 876_ CINML 881_ KLPEY 886_ PSKEI 891_ LKDRL 896_ LVALH 901_CGSYG
1: E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases (PubMed:15254018, PubMed:21988917, PubMed:22036506, PubMed:37537642, PubMed:38332367). Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion (PubMed:21988917). Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division (PubMed:21988917). Specifically binds GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens (PubMed:22036506, PubMed:37537642, PubMed:38332367). May also act as a transcription regulator via its interaction with RARB (By similarity)