Calcium uptake protein 2, mitochondrial (EF-hand domain-containing family member A1)
1_MAAAA 6_ GSCAR 11_ VAAWG 16_ GKLRR 21_ GLAVS 26_ RQAVR 31_ SPGPL 36_ AAAVA 41_ GAALA 46_ GAGAA 51_ WHHSR 56_ VSVAA 61_ RDGSF 66_ TVSAQ 71_ KNVEH 76_ GIIYI 81_ GKPSL 86_ RKQRF 91_ MQFSS 96_ LEHEG 101_ EYYMT 106_ PRDFL 111_ FSVMF 116_ EQMER 121_ KTSVK 126_ KLTKK 131_ DIEDT 136_ LSGIQ 141_ TAGCG 146_ STFFR 151_ DLGDK 156_ GLISY 161_ TEYLF 166_ LLTIL 171_ TKPHS 176_ GFHVA 181_ FKMLD 186_ TDGNE 191_ MIEKR 196_ EFFKL 201_ QKIIS 206_ KQDDL 211_ MTVKT 216_ NETGY 221_ QEAIV 226_ KEPEI 231_ NTTLQ 236_ MRFFG 241_ KRGQR 246_ KLHYK 251_ EFRRF 256_ MENLQ 261_ TEIQE 266_ MEFLQ 271_ FSKGL 276_ SFMRK 281_ EDFAE 286_ WLLFF 291_ TNTEN 296_ KDIYW 301_ KNVRE 306_ KLSAG 311_ ESISL 316_ DEFKS 321_ FCHFT 326_ THLED 331_ FAIAM 336_ QMFSL 341_ AHRPV 346_ RLAEF 351_ KRAVK 356_ VATGQ 361_ ELSNN 366_ ILDTV 371_ FKIFD 376_ LDGDE 381_ CLSHE 386_ EFLGV 391_ LKNRM 396_ HRGLW 401_ VPQHQ 406_ SIQEY 411_ WKCVK 416_ KESIK 421_ GVKEV 426_WKQAG
1: Calcium sensor of the mitochondrial calcium uniporter (MCU) channel, which senses calcium level via its EF-hand domains (PubMed:24503055, PubMed:24560927, PubMed:26903221, PubMed:28615291, PubMed:30699349, PubMed:31397067, PubMed:32494073, PubMed:32667285, PubMed:32762847, PubMed:32790952). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium (PubMed:24560927, PubMed:26903221, PubMed:28615291, PubMed:30699349, PubMed:31397067, PubMed:32148862, PubMed:32494073, PubMed:32667285, PubMed:32762847, PubMed:32790952). At low calcium levels, MICU1 occludes the pore of the MCU channel, preventing mitochondrial calcium uptake (PubMed:32494073, PubMed:32667285, PubMed:32762847). At higher calcium levels, calcium-binding to MICU1 and MICU2 induces a conformational change that weakens MCU-MICU1 interactions and moves the MICU1-MICU2 heterodimer away from the pore, allowing calcium permeation through the MCU channel (PubMed:32494073, PubMed:32667285, PubMed:32762847)