TBC1 domain family member 21 (Male germ cell Rab GTPase-activating protein)
1_MTTLS 6_ PENSL 11_ SARQS 16_ ASFIL 21_ VKRKP 26_ PIDKT 31_ EWDSF 36_ FDESG 41_ HLAKS 46_ RDFIC 51_ VNILE 56_ RGLHP 61_ FVRTE 66_ AWKFL 71_ TGYFS 76_ WQSSQ 81_ DERLT 86_ VDSMR 91_ RKNYK 96_ ALCQM 101_ YEKIQ 106_ PLLEN 111_ LHRNF 116_ TETRN 121_ NIARD 126_ IQKIY 131_ DKDPL 136_ GNVLI 141_ DKKRL 146_ EKILL 151_ LSYVC 156_ NTQAE 161_ YQQGF 166_ HEMMM 171_ LFQLM 176_ VEHDH 181_ ETFWL 186_ FQFFL 191_ QKTEH 196_ SCVIN 201_ IGVAK 206_ NLDML 211_ STLIT 216_ FLDPV 221_ FAEHL 226_ KGKGA 231_ GAVQS 236_ LFPWF 241_ CFCFQ 246_ RAFKS 251_ FDDVW 256_ RLWEV 261_ LLTGK 266_ PCRNF 271_ QVLVA 276_ YSMLQ 281_ MVREQ 286_ VLQES 291_ MGGDD 296_ ILLAC 301_ NNLID 306_ LDADE 311_ LISAA 316_ CVVYA 321_ ELIQK 326_ DVPQT 331_LKDFF
1: Acts as a GTPase-activating protein for Rab family protein(s) (PubMed:19077034, PubMed:28067790). Essential for the establishment of male fertility, and is required for both the production of normal sperm number and sperm function (By similarity). Plays an important role in the formation of intact mitochondria, outer dense fibers and axoneme within the sperm tail (By similarity). Essential for sperm mitochondrial sheath formation and for the interactions of ARMC12 with VDAC2 and VDAC3 (By similarity). May be involved in acrosome formation and cytoskeletal reorganization during spermiogenesis, possibly by regulating RAB3A activity (PubMed:21128978)