Tissue-resident T-cell transcription regulator protein ZNF683 (Homolog of Blimp-1 in T-cell) (Hobit) (Zinc finger protein 683)
1_MKEES 6_ AAQLG 11_ CCHRP 16_ MALGG 21_ TGGSL 26_ SPSLD 31_ FQLFR 36_ GDQVF 41_ SACRP 46_ LPDMV 51_ DAHGP 56_ SCASW 61_ LCPLP 66_ LAPGR 71_ SALLA 76_ CLQDL 81_ DLNLC 86_ TPQPA 91_ PLGTD 96_ LQGLQ 101_ EDALS 106_ MKHEP 111_ PGLQA 116_ SSTDD 121_ KKFTV 126_ KYPQN 131_ KDKLG 136_ KQPER 141_ AGEGA 146_ PCPAF 151_ SSHNS 156_ SSPPP 161_ LQNRK 166_ SPSPL 171_ AFCPC 176_ PPVNS 181_ ISKEL 186_ PFLLH 191_ AFYPG 196_ YPLLL 201_ PPPHL 206_ FTYGA 211_ LPSDQ 216_ CPHLL 221_ MLPQD 226_ PSYPT 231_ MAMPS 236_ LLMMV 241_ NELGH 246_ PSARW 251_ ETLLP 256_ YPGAF 261_ QASGQ 266_ ALPSQ 271_ ARNPG 276_ AGAAP 281_ TDSPG 286_ LERGG 291_ MASPA 296_ KRVPL 301_ SSQTG 306_ TAALP 311_ YPLKK 316_ KNGKI 321_ LYECN 326_ ICGKS 331_ FGQLS 336_ NLKVH 341_ LRVHS 346_ GERPF 351_ QCALC 356_ QKSFT 361_ QLAHL 366_ QKHHL 371_ VHTGE 376_ RPHKC 381_ SIPWV 386_ PGRNH 391_ WKSFQ 396_ AWRER 401_ EVCHK 406_ RFSSS 411_ SNLKT 416_ HLRLH 421_ SGARP 426_ FQCSV 431_ CRSRF 436_ TQHIH 441_ LKLHH 446_ RLHAP 451_ QPCGL 456_ VHTQL 461_ PLASL 466_ ACLAQ 471_ WHQGA 476_ LDLMA 481_ VASEK 486_ HMGYD 491_ IDEVK 496_ VSSTS 501_ QGKAR 506_ AVSLS 511_ SAGTP 516_LVMGQ
1: Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T-cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Also plays a role in the differentiation of both thymic and peripheral NKT cells. Negatively regulates the accumulation of interferon-gamma (IFN-gamma) in NKT cells at steady state or after antigenic stimulation. Positively regulates granzyme B production in NKT cells after innate stimulation. Associates with the transcriptional repressor PRDM1/BLIMP1 to chromatin at gene promoter regions
2: Lacks transcriptional repressor activity. Binds to DNA within promoter regions of the transcriptional repressor PRDM1/BLIMP1 target sites. Unable to regulate interferon-gamma (IFN-gamma) production in cytomegalovirus (CMV)-infected effector CD8(+) T-cells
3: Transcriptional repressor that binds to DNA within promoter regions of the transcriptional repressor PRDM1/BLIMP1 target sites. Regulates interferon-gamma (IFN-gamma) production in cytomegalovirus (CMV)-infected effector CD8(+) T cells