Phosphatase and actin regulator 4
1_MEDPF 6_ EEADQ 11_ PTTEP 16_ GMVLD 21_ SVEAG 26_ DTTPP 31_ TKRKS 36_ KFSGF 41_ GKIFK 46_ PWKWR 51_ KKKSS 56_ DKFKE 61_ TSEVL 66_ ERKIS 71_ MRKPR 76_ EELVK 81_ RGVLL 86_ EDPEQ 91_ GGEDP 96_ GKPSD 101_ AMLKN 106_ GHTTP 111_ IGNAR 116_ SSSPV 121_ QVEEE 126_ PVRLA 131_ SLRKA 136_ IPEED 141_ LKKRL 146_ GSTGS 151_ QPNSE 156_ AESVP 161_ ENVPK 166_ PPLLP 171_ PKRPL 176_ SSSHE 181_ ASEGQ 186_ AKDAT 191_ SSGGT 196_ ARFII 201_ STSIT 206_ TAPAA 211_ TTAAT 216_ SLAKT 221_ VNLSV 226_ TPSPA 231_ PRTLP 236_ AAPAS 241_ TNTTA 246_ TPSLT 251_ HMVPA 256_ KQPPI 261_ PPPKP 266_ AHRNS 271_ NPVIA 276_ ELSQA 281_ INSGT 286_ LLSKP 291_ SPPLP 296_ PKRGI 301_ PSTSV 306_ PTLES 311_ AAAIT 316_ TKTPS 321_ DEREK 326_ STCSM 331_ GSELL 336_ PMISP 341_ RSPSP 346_ PLPTH 351_ IPPEP 356_ PRTPP 361_ FPAKT 366_ FQVVP 371_ EIEFP 376_ PSLDL 381_ HQEIP 386_ QQEDQ 391_ KKEVP 396_ KRILD 401_ QNFGE 406_ PHIPS 411_ RLPPL 416_ PLHIR 421_ IQQAL 426_ TSPLP 431_ MTPIL 436_ EGSHR 441_ AHSLL 446_ FENSD 451_ SFSED 456_ SSTLG 461_ RTRSL 466_ PITIE 471_ MLKVP 476_ DDEEE 481_ EEQTC 486_ PSTFS 491_ EEMTP 496_ TSVIP 501_ KLPQC 506_ LREEE 511_ EKESD 516_ SDSEG 521_ PIQYR 526_ DEEDE 531_ DESYQ 536_ SALAN 541_ KVKRK 546_ DTLAM 551_ KLNHR 556_ PSEPE 561_ LNLNS 566_ WPCKS 571_ KEEWN 576_ EIRHQ 581_ IGNTL 586_ IRRLS 591_ QRPTP 596_ EELEQ 601_ RNILQ 606_ PKNEA 611_ DRQAE 616_ KREIK 621_ RRLTR 626_ KLSQR 631_ PTVAE 636_ LLARK 641_ ILRFN 646_ EYVEV 651_ TDAQD 656_ YDRRA 661_ DKPWT 666_ KLTPA 671_ DKAAI 676_ RKELN 681_ EFKSS 686_ EMEVH 691_ EESKH 696_FTRYH
1: Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity)