Chondroitin sulfate synthase 2 (EC 2.4.1.175) (EC 2.4.1.226) (Chondroitin glucuronyltransferase 2) (Chondroitin-polymerizing factor) (ChPF) (Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase II) (N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase II) (N-acetylgalactosaminyltransferase 2)
1_MRASL 6_ LLSVL 11_ RPAGP 16_ VAVGI 21_ SLGFT 26_ LSLLS 31_ VTWVE 36_ EPCGP 41_ GPPQP 46_ GDSEL 51_ PPRGN 56_ TNAAR 61_ RPNSV 66_ QPGAE 71_ REKPG 76_ AGEGA 81_ GENWE 86_ PRVLP 91_ YHPAQ 96_ PGQAA 101_ KKAVR 106_ TRYIS 111_ TELGI 116_ RQRLL 121_ VAVLT 126_ SQTTL 131_ PTLGV 136_ AVNRT 141_ LGHRL 146_ ERVVF 151_ LTGAR 156_ GRRAP 161_ PGMAV 166_ VTLGE 171_ ERPIG 176_ HLHLA 181_ LRHLL 186_ EQHGD 191_ DFDWF 196_ FLVPD 201_ TTYTE 206_ AHGLA 211_ RLTGH 216_ LSLAS 221_ AAHLY 226_ LGRPQ 231_ DFIGG 236_ EPTPG 241_ RYCHG 246_ GFGVL 251_ LSRML 256_ LQQLR 261_ PHLEG 266_ CRNDI 271_ VSARP 276_ DEWLG 281_ RCILD 286_ ATGVG 291_ CTGDH 296_ EGVHY 301_ SHLEL 306_ SPGEP 311_ VQEGD 316_ PHFRS 321_ ALTAH 326_ PVRDP 331_ VHMYQ 336_ LHKAF 341_ ARAEL 346_ ERTYQ 351_ EIQEL 356_ QWEIQ 361_ NTSHL 366_ AVDGD 371_ QAAAW 376_ PVGIP 381_ APSRP 386_ ASRFE 391_ VLRWD 396_ YFTEQ 401_ HAFSC 406_ ADGSP 411_ RCPLR 416_ GADRA 421_ DVADV 426_ LGTAL 431_ EELNR 436_ RYHPA 441_ LRLQK 446_ QQLVN 451_ GYRRF 456_ DPARG 461_ MEYTL 466_ DLQLE 471_ ALTPQ 476_ GGRRP 481_ LTRRV 486_ QLLRP 491_ LSRVE 496_ ILPVP 501_ YVTEA 506_ SRLTV 511_ LLPLA 516_ AAERD 521_ LAPGF 526_ LEAFA 531_ TAALE 536_ PGDAA 541_ AALTL 546_ LLLYE 551_ PRQAQ 556_ RVAHA 561_ DVFAP 566_ VKAHV 571_ AELER 576_ RFPGA 581_ RVPWL 586_ SVQTA 591_ APSPL 596_ RLMDL 601_ LSKKH 606_ PLDTL 611_ FLLAG 616_ PDTVL 621_ TPDFL 626_ NRCRM 631_ HAISG 636_ WQAFF 641_ PMHFQ 646_ AFHPA 651_ VAPPQ 656_ GPGPP 661_ ELGRD 666_ TGRFD 671_ RQAAS 676_ EACFY 681_ NSDYV 686_ AARGR 691_ LAAAS 696_ EQEEE 701_ LLESL 706_ DVYEL 711_ FLHFS 716_ SLHVL 721_ RAVEP 726_ ALLQR 731_ YRAQT 736_ CSARL 741_ SEDLY 746_ HRCLQ 751_ SVLEG 756_ LGSRT 761_ QLAML 766_LFEQE
1: Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Seems to act as a specific activating factor for CHSY1 in chondroitin polymerization (PubMed:12716890)
2: May facilitate PRKN transport into the mitochondria. In collaboration with PRKN, may enhance cell viability and protect cells from oxidative stress