Histone H1.8 (Histone H1oo) (Oocyte-specific histone H1) (Oocyte-specific linker histone H1) (osH1)
1_MAPGS 6_ VTSDI 11_ SPSST 16_ STAGS 21_ SRSPE 26_ SEKPG 31_ PSHGG 36_ VPPGG 41_ PSHSS 46_ LPVGR 51_ RHPPV 56_ LRMVL 61_ EALQA 66_ GEQRR 71_ GTSVA 76_ AIKLY 81_ ILHKY 86_ PTVDV 91_ LRFKY 96_ LLKQA 101_ LATGM 106_ RRGLL 111_ ARPLN 116_ SKARG 121_ ATGSF 126_ KLVPK 131_ HKKKI 136_ QPRKM 141_ APATA 146_ PRRAG 151_ EAKGK 156_ GPKKP 161_ SEAKE 166_ DPPNV 171_ GKVKK 176_ AAKRP 181_ AKVQK 186_ PPPKP 191_ GAATE 196_ KARKQ 201_ GGAAK 206_ DTRAQ 211_ SGEAR 216_ KVPPK 221_ PDKAM 226_ RAPSS 231_ AGGLS 236_ RKAKA 241_ KGSRS 246_ SQGDA 251_ EAYRK 256_ TKAES 261_ KSSKP 266_ TASKV 271_ KNGAA 276_ SPTKK 281_ KVVAK 286_ AKAPK 291_ AGQGP 296_ NTKAA 301_ APAKG 306_ SGSKV 311_ VPAHL 316_ SRKTE 321_ APKGP 326_ RKAGL 331_ PIKAS 336_ SSKVS 341_SQRAE
1: May play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role in nuclear remodeling (By similarity)