Inactive histone-lysine N-methyltransferase 2E (Inactive lysine N-methyltransferase 2E) (Myeloid/lymphoid or mixed-lineage leukemia protein 5)
1_MSIVI 6_ PLGVD 11_ TAETS 16_ YLEMA 21_ AGSEP 26_ ESVEA 31_ SPVVV 36_ EKSNS 41_ YPHQL 46_ YTSSS 51_ HHSHS 56_ YIGLP 61_ YADHN 66_ YGARP 71_ PPTPP 76_ ASPPP 81_ SVLIS 86_ KNEVG 91_ IFTTP 96_ NFDET 101_ SSATT 106_ ISTSE 111_ DGSYG 116_ TDVTR 121_ CICGF 126_ THDDG 131_ YMICC 136_ DKCSV 141_ WQHID 146_ CMGID 151_ RQHIP 156_ DTYLC 161_ ERCQP 166_ RNLDK 171_ ERAVL 176_ LQRRK 181_ RENMS 186_ DGDTS 191_ ATESG 196_ DEVPV 201_ ELYTA 206_ FQHTP 211_ TSITL 216_ TASRV 221_ SKVND 226_ KRRKK 231_ SGEKE 236_ QHISK 241_ CKKAF 246_ REGSR 251_ KSSRV 256_ KGSAP 261_ EIDPS 266_ SDGSN 271_ FGWET 276_ KIKAW 281_ MDRYE 286_ EANNN 291_ QYSEG 296_ VQREA 301_ QRIAL 306_ RLGNG 311_ NDKKE 316_ MNKSD 321_ LNTNN 326_ LLFKP 331_ PVESH 336_ IQKNK 341_ KILKS 346_ AKDLP 351_ PDALI 356_ IEYRG 361_ KFMLR 366_ EQFEA 371_ NGYFF 376_ KRPYP 381_ FVLFY 386_ SKFHG 391_ LEMCV 396_ DARTF 401_ GNEAR 406_ FIRRS 411_ CTPNA 416_ EVRHE 421_ IQDGT 426_ IHLYI 431_ YSIHS 436_ IPKGT 441_ EITIA 446_ FDFDY 451_ GNCKY 456_ KVDCA 461_ CLKEN 466_ PECPV 471_ LKRSS 476_ ESMEN 481_ INSGY 486_ ETRRK 491_ KGKKD 496_ KDISK 501_ EKDTQ 506_ NQNIT 511_ LDCEG 516_ TTNKM 521_ KSPET 526_ KQRKL 531_ SPLRL 536_ SVSNN 541_ QEPDF 546_ IDDIE 551_ EKTPI 556_ SNEVE 561_ MESEE 566_ QIAER 571_ KRKMT 576_ REERK 581_ MEAIL 586_ QAFAR 591_ LEKRE 596_ KRREQ 601_ ALERI 606_ STAKT 611_ EVKTE 616_ CKDTQ 621_ IVSDA 626_ EVIQE 631_ QAKEE 636_ NASKP 641_ TPAKV 646_ NRTKQ 651_ RKSFS 656_ RSRTH 661_ IGQQR 666_ RRHRT 671_ VSMCS 676_ DIQPS 681_ SPDIE 686_ VTSQQ 691_ NDIEN 696_ TVLTI 701_ EPETE 706_ TALAE 711_ IITET 716_ EVPAL 721_ NKCPT 726_ KYPKT 731_ KKHLV 736_ NEWLS 741_ EKNEK 746_ TGKPS 751_ DGLSE 756_ RPLRI 761_ TTDPE 766_ VLATQ 771_ LNSLP 776_ GLTYS 781_ PHVYS 786_ TPKHY 791_ IRFTS 796_ PFLSE 801_ KRRRK 806_ EPTEN 811_ ISGSC 816_ KKRWL 821_ KQALE 826_ EENSA 831_ ILHRF 836_ NSPCQ 841_ ERSRS 846_ PAVNG 851_ ENKSP 856_ LLLND 861_ SCSLP 866_ DLTTP 871_ LKKRR 876_ FYQLL 881_ DSVYS 886_ ETSTP 891_ TPSPY 896_ ATPTH 901_ TDITP 906_ MDPSF 911_ ATPPR 916_ IKSDD 921_ ETCRN 926_ GYKPI 931_ YSPVT 936_ PVTPG 941_ TPGNT 946_ MHFEN 951_ ISSPE 956_ SSPEI 961_ KRRTY 966_ SQEGY 971_ DRSST 976_ MLTLG 981_ PFRNS 986_ NLTEL 991_ GLQEI 996_ KTIGY 1001_ TSPRS 1006_ RTEVN 1011_ RQCPG 1016_ EKEPV 1021_ SDLQL 1026_ GLDAV 1031_ EPTAL 1036_ HKTLE 1041_ TPAHD 1046_ RAEPN 1051_ SQLDS 1056_ THSGR 1061_ GTMYS 1066_ SWVKS 1071_ PDRTG 1076_ VNFSV 1081_ NSNLR 1086_ DLTPS 1091_ HQLEV 1096_ GGGFR 1101_ ISESK 1106_ CLMQD 1111_ DTRGM 1116_ FMETT 1121_ VFCTS 1126_ EDGLV 1131_ SGFGR 1136_ TVNDN 1141_ LIDGN 1146_ CTPQN 1151_ PPQKK 1156_ KVSLL 1161_ EYRKR 1166_ QREAR 1171_ KSGSK 1176_ TENFP 1181_ LISVS 1186_ PHASG 1191_ SLSNN 1196_ GDGCA 1201_ SSNDN 1206_ GEQVD 1211_ HTASL 1216_ PLPTP 1221_ ATVYN 1226_ ATSEE 1231_ TSNNC 1236_ PVKDA 1241_ TASEK 1246_ NEPEV 1251_ QWTAS 1256_ TSVEQ 1261_ VRERS 1266_ YQRAL 1271_ LLSDH 1276_ RKDKD 1281_ SGGES 1286_ PCVSC 1291_ SPSHV 1296_ QSSPS 1301_ SHSNH 1306_ IPQLQ 1311_ AKGPV 1316_ PSFSE 1321_ LMEDP 1326_ DPENP 1331_ EPTTT 1336_ NECPS 1341_ PDTSQ 1346_ NTCKS 1351_ PPKMS 1356_ KPGSP 1361_ GSVIP 1366_ AQAHG 1371_ KIFTK 1376_ PDPQW 1381_ DSTVS 1386_ ASEAE 1391_ NGVHL 1396_ KTELQ 1401_ QKQLS 1406_ NNNQA 1411_ LSKNH 1416_ PPQTH 1421_ VRNSS 1426_ EQLSQ 1431_ KLPSV 1436_ PTKLH 1441_ CPPSP 1446_ HLENP 1451_ PKSST 1456_ PHTPV 1461_ QHGYL 1466_ SPKPP 1471_ SQQLG 1476_ SPYRP 1481_ HHSQS 1486_ PQVGT 1491_ PQREP 1496_ QRNFY 1501_ PAAQN 1506_ LPANT 1511_ QQATS 1516_ GTLFT 1521_ QTPSG 1526_ QSSAT 1531_ YSQFN 1536_ QQSLN 1541_ STAPP 1546_ PPPPP 1551_ PPSSS 1556_ YYQNQ 1561_ QPSAN 1566_ FQNYN 1571_ QLKGS 1576_ LSQQT 1581_ VFTSG 1586_ PNQAL 1591_ PGTTS 1596_ QQTVP 1601_ GHHVT 1606_ PGHFL 1611_ PSQNP 1616_ TIHHQ 1621_ TAAAV 1626_ VPPPP 1631_ PPPPA 1636_ PGPHL 1641_ VQQPN 1646_ SHQQH 1651_ SVAHV 1656_ VGPVH 1661_ AVTPG 1666_ SHIHS 1671_ QTAGH 1676_ HLPPP 1681_ PPPPG 1686_ PAPHH 1691_ HPPPH 1696_ PSTGL 1701_ QGLQA 1706_ QHQHV 1711_ VNSAP 1716_ PPPPP 1721_ PPPSS 1726_ VLASG 1731_ HHTTS 1736_ AQALH 1741_ HPPHQ 1746_ GPPLF 1751_ PSSAH 1756_ PTVPP 1761_ YPSQA 1766_ THHTT 1771_ LGPGP 1776_ QHQPS 1781_ GTGPH 1786_ CPLPV 1791_ TGPHL 1796_ QPQGP 1801_ NSIPT 1806_ PTASG 1811_ FCPHP 1816_ GSVAL 1821_ PHGVQ 1826_ GPQQA 1831_ SPVPG 1836_ QIPIH 1841_ RAQVP 1846_ PTFQN 1851_NYHGS
1: Associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription (PubMed:23629655, PubMed:23798402, PubMed:24130829). Chromatin interaction is mediated via the binding to tri-methylated histone H3 at 'Lys-4' (H3K4me3) (PubMed:23798402, PubMed:24130829). Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation (By similarity). Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages including G1/S transition, S phase progression and mitotic entry (PubMed:14718661, PubMed:18573682, PubMed:19264965, PubMed:23629655). Recruited to E2F1 responsive promoters by HCFC1 where it stimulates tri-methylation of histone H3 at 'Lys-4' and transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). During myoblast differentiation, required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells (By similarity)
2: Cellular ligand for NCR2/NKp44, may play a role as a danger signal in cytotoxicity and NK-cell-mediated innate immunity