Solute carrier family 22 member 15 (Fly-like putative transporter 1) (Flipt 1)
1_MEVEE 6_ AFQAV 11_ GEMGI 16_ YQMYL 21_ CFLLA 26_ VLLQL 31_ YVATE 36_ AILIA 41_ LVGAT 46_ PSYHW 51_ DLAEL 56_ LPNQS 61_ HGNQS 66_ AGEDQ 71_ AFGDW 76_ LLTAN 81_ GSEIH 86_ KHVHF 91_ SSSFT 96_ SIASE 101_ WFLIA 106_ NRSYK 111_ VSAAS 116_ SFFFS 121_ GVFVG 126_ VISFG 131_ QLSDR 136_ FGRKK 141_ VYLTG 146_ FALDI 151_ LFAIA 156_ NGFSP 161_ SYEFF 166_ AVTRF 171_ LVGMM 176_ NGGMS 181_ LVAFV 186_ LLNEC 191_ VGTAY 196_ WALAG 201_ SIGGL 206_ FFAVG 211_ IAQYA 216_ LLGYF 221_ IRSWR 226_ TLAIL 231_ VNLQG 236_ TVVFL 241_ LSLFI 246_ PESPR 251_ WLYSQ 256_ GRLSE 261_ AEEAL 266_ YLIAK 271_ RNRKL 276_ KCTFS 281_ LTHPA 286_ NRSCR 291_ ETGSF 296_ LDLFR 301_ YRVLL 306_ GHTLI 311_ LMFIW 316_ FVCSL 321_ VYYGL 326_ TLSAG 331_ DLGGS 336_ IYANL 341_ ALSGL 346_ IEIPS 351_ YPLCI 356_ YLINQ 361_ KWFGR 366_ KRTLS 371_ AFLCL 376_ GGLAC 381_ LIVMF 386_ LPEKK 391_ DTGVF 396_ AVVNS 401_ HSLSL 406_ LGKLT 411_ ISAAF 416_ NIVYI 421_ YTSEL 426_ YPTVI 431_ RNVGL 436_ GTCSM 441_ FSRVG 446_ GIIAP 451_ FIPSL 456_ KYVQW 461_ SLPFI 466_ VFGAT 471_ GLTSG 476_ LLSLL 481_ LPETL 486_ NSPLL 491_ ETFSD 496_ LQVYS 501_ YRRLG 506_ EEALS 511_ LQALD 516_ PQQCV 521_ DKESS 526_ LGSES 531_ EEEEE 536_ FYDAD 541_EETQM
1: Organic zwitterion/cation transporter with apparent specificity for amino acids and their derivatives. Has low affinity for its substrates and may regulate their flux across the plasma membrane at high substrate concentrations (PubMed:33124720). Bidirectionally transports carnitine and acetylcarnitine, possibly regulating their cytosolic abundance and further fatty acid catabolism via beta oxidation (PubMed:33124720). Displays high transport activity toward zwitterionic substrates such as glycine betaine and diet-derived ergothioneine and carnosine. Can transport cations having an indole skeleton such as thiamine with lower efficiency. Does not transport agmatine (PubMed:15028572, PubMed:33124720). The transport mechanism, symport with sodium or facilitated diffusion allosterically regulated by sodium, remains to be elucidated (Probable)