Sodium leak channel NALCN (CanIon) (Sodium leak channel non-selective protein) (Voltage gated channel-like protein 1)
1_MLKRK 6_ QSSRV 11_ EAQPV 16_ TDFGP 21_ DESLS 26_ DNADI 31_ LWINK 36_ PWVHS 41_ LLRIC 46_ AIISV 51_ ISVCM 56_ NTPMT 61_ FEHYP 66_ PLQYV 71_ TFTLD 76_ TLLMF 81_ LYTAE 86_ MIAKM 91_ HIRGI 96_ VKGDS 101_ SYVKD 106_ RWCVF 111_ DGFMV 116_ FCLWV 121_ SLVLQ 126_ VFEIA 131_ DIVDQ 136_ MSPWG 141_ MLRIP 146_ RPLIM 151_ IRAFR 156_ IYFRF 161_ ELPRT 166_ RITNI 171_ LKRSG 176_ EQIWS 181_ VSIFL 186_ LFFLL 191_ LYGIL 196_ GVQMF 201_ GTFTY 206_ HCVVN 211_ DTKPG 216_ NVTWN 221_ SLAIP 226_ DTHCS 231_ PELEE 236_ GYQCP 241_ PGFKC 246_ MDLED 251_ LGLSR 256_ QELGY 261_ SGFNE 266_ IGTSI 271_ FTVYE 276_ AASQE 281_ GWVFL 286_ MYRAI 291_ DSFPR 296_ WRSYF 301_ YFITL 306_ IFFLA 311_ WLVKN 316_ VFIAV 321_ IIETF 326_ AEIRV 331_ QFQQM 336_ WGSRS 341_ STTST 346_ ATTQM 351_ FHEDA 356_ AGGWQ 361_ LVAVD 366_ VNKPQ 371_ GRAPA 376_ CLQKM 381_ MRSSV 386_ FHMFI 391_ LSMVT 396_ VDVIV 401_ AASNY 406_ YKGEN 411_ FRRQY 416_ DEFYL 421_ AEVAF 426_ TVLFD 431_ LEALL 436_ KIWCL 441_ GFTGY 446_ ISSSL 451_ HKFEL 456_ LLVIG 461_ TTLHV 466_ YPDLY 471_ HSQFT 476_ YFQVL 481_ RVVRL 486_ IKISP 491_ ALEDF 496_ VYKIF 501_ GPGKK 506_ LGSLV 511_ VFTAS 516_ LLIVM 521_ SAISL 526_ QMFCF 531_ VEELD 536_ RFTTF 541_ PRAFM 546_ SMFQI 551_ LTQEG 556_ WVDVM 561_ DQTLN 566_ AVGHM 571_ WAPVV 576_ AIYFI 581_ LYHLF 586_ ATLIL 591_ LSLFV 596_ AVILD 601_ NLELD 606_ EDLKK 611_ LKQLK 616_ QSEAN 621_ ADTKE 626_ KLPLR 631_ LRIFE 636_ KFPNR 641_ PQMVK 646_ ISKLP 651_ SDFTV 656_ PKIRE 661_ SFMKQ 666_ FIDRQ 671_ QQDTC 676_ CLLRS 681_ LPTTS 686_ SSSCD 691_ HSKRS 696_ AIEDN 701_ KYIDQ 706_ KLRKS 711_ VFSIR 716_ ARNLL 721_ EKETA 726_ VTKIL 731_ RACTR 736_ QRMLS 741_ GSFEG 746_ QPAKE 751_ RSILS 756_ VQHHI 761_ RQERR 766_ SLRHG 771_ SNSQR 776_ ISRGK 781_ SLETL 786_ TQDHS 791_ NTVRY 796_ RNAQR 801_ EDSEI 806_ KMIQE 811_ KKEQA 816_ EMKRK 821_ VQEEE 826_ LRENH 831_ PYFDK 836_ PLFIV 841_ GREHR 846_ FRNFC 851_ RVVVR 856_ ARFNA 861_ SKTDP 866_ VTGAV 871_ KNTKY 876_ HQLYD 881_ LLGLV 886_ TYLDW 891_ VMIIV 896_ TICSC 901_ ISMMF 906_ ESPFR 911_ RVMHA 916_ PTLQI 921_ AEYVF 926_ VIFMS 931_ IELNL 936_ KIMAD 941_ GLFFT 946_ PTAVI 951_ RDFGG 956_ VMDIF 961_ IYLVS 966_ LIFLC 971_ WMPQN 976_ VPAES 981_ GAQLL 986_ MVLRC 991_ LRPLR 996_ IFKLV 1001_ PQMRK 1006_ VVREL 1011_ FSGFK 1016_ EIFLV 1021_ SILLL 1026_ TLMLV 1031_ FASFG 1036_ VQLFA 1041_ GKLAK 1046_ CNDPN 1051_ IIRRE 1056_ DCNGI 1061_ FRINV 1066_ SVSKN 1071_ LNLKL 1076_ RPGEK 1081_ KPGFW 1086_ VPRVW 1091_ ANPRN 1096_ FNFDN 1101_ VGNAM 1106_ LALFE 1111_ VLSLK 1116_ GWVEV 1121_ RDVII 1126_ HRVGP 1131_ IHGIY 1136_ IHVFV 1141_ FLGCM 1146_ IGLTL 1151_ FVGVV 1156_ IANFN 1161_ ENKGT 1166_ ALLTV 1171_ DQRRW 1176_ EDLKS 1181_ RLKIA 1186_ QPLHL 1191_ PPRPD 1196_ NDGFR 1201_ AKMYD 1206_ ITQHP 1211_ FFKRT 1216_ IALLV 1221_ LAQSV 1226_ LLSVK 1231_ WDVED 1236_ PVTVP 1241_ LATMS 1246_ VVFTF 1251_ IFVLE 1256_ VTMKI 1261_ IAMSP 1266_ AGFWQ 1271_ SRRNR 1276_ YDLLV 1281_ TSLGV 1286_ VWVVL 1291_ HFALL 1296_ NAYTY 1301_ MMGAC 1306_ VIVFR 1311_ FFSIC 1316_ GKHVT 1321_ LKMLL 1326_ LTVVV 1331_ SMYKS 1336_ FFIIV 1341_ GMFLL 1346_ LLCYA 1351_ FAGVV 1356_ LFGTV 1361_ KYGEN 1366_ INRHA 1371_ NFSSA 1376_ GKAIT 1381_ VLFRI 1386_ VTGED 1391_ WNKIM 1396_ HDCMV 1401_ QPPFC 1406_ TPDEF 1411_ TYWAT 1416_ DCGNY 1421_ AGALM 1426_ YFCSF 1431_ YVIIA 1436_ YIMLN 1441_ LLVAI 1446_ IVENF 1451_ SLFYS 1456_ TEEDQ 1461_ LLSYN 1466_ DLRHF 1471_ QIIWN 1476_ MVDDK 1481_ REGVI 1486_ PTFRV 1491_ KFLLR 1496_ LLRGR 1501_ LEVDL 1506_ DKDKL 1511_ LFKHM 1516_ CYEME 1521_ RLHNG 1526_ GDVTF 1531_ HDVLS 1536_ MLSYR 1541_ SVDIR 1546_ KSLQL 1551_ EELLA 1556_ REQLE 1561_ YTIEE 1566_ EVAKQ 1571_ TIRMW 1576_ LKKCL 1581_ KRIRA 1586_ KQQQS 1591_ CSIIH 1596_ SLRES 1601_ QQQEL 1606_ SRFLN 1611_ PPSIE 1616_ TTQPS 1621_ EDTNA 1626_ NSQDN 1631_ SMQPE 1636_ TSSQQ 1641_ QLLSP 1646_ TLSDR 1651_ GGSRQ 1656_ DAADA 1661_ GKPQR 1666_ KFGQW 1671_ RLPSA 1676_ PKPIS 1681_ HSVSS 1686_ VNLRF 1691_ GGRTT 1696_ MKSVV 1701_ CKMNP 1706_ MTDAA 1711_ SCGSE 1716_ VKKWW 1721_ TRQLT 1726_ VESDE 1731_SGDDL
1: Voltage-gated ion channel responsible for the resting Na(+) permeability that controls neuronal excitability (PubMed:17448995, PubMed:31409833). NALCN channel functions as a multi-protein complex, which consists at least of NALCN, NALF1, UNC79 and UNC80 (PubMed:32494638, PubMed:33203861). NALCN is the voltage-sensing, pore-forming subunit of the NALCN channel complex (PubMed:17448995). NALCN channel complex is constitutively active and conducts monovalent cations but is blocked by physiological concentrations of extracellular divalent cations (PubMed:32494638). In addition to its role in regulating neuronal excitability, is required for normal respiratory rhythm, systemic osmoregulation by controlling the serum sodium concentration and in the regulation of the intestinal pace-making activity in the interstitial cells of Cajal (By similarity). NALCN channel is also activated by neuropeptides such as neurotensin and substance P (SP) through a SRC family kinases-dependent pathway (By similarity). In addition, NALCN activity is enhanced/modulated by several GPCRs, such as CHRM3 (By similarity)