5'-3' exoribonuclease 1 (EC 3.1.13.-) (Strand-exchange protein 1 homolog)
1_MGVPK 6_ FYRWI 11_ SERYP 16_ CLSEV 21_ VKEHQ 26_ IPEFD 31_ NLYLD 36_ MNGII 41_ HQCSH 46_ PNDDD 51_ VHFRI 56_ SDDKI 61_ FTDIF 66_ HYLEV 71_ LFRII 76_ KPRKV 81_ FFMAV 86_ DGVAP 91_ RAKMN 96_ QQRGR 101_ RFRSA 106_ KEAED 111_ KIKKA 116_ IEKGE 121_ TLPTE 126_ ARFDS 131_ NCITP 136_ GTEFM 141_ ARLHE 146_ HLKYF 151_ VNMKI 156_ STDKS 161_ WQGVT 166_ IYFSG 171_ HETPG 176_ EGEHK 181_ IMEFI 186_ RSEKA 191_ KPDHD 196_ PNTRH 201_ CLYGL 206_ DADLI 211_ MLGLT 216_ SHEAH 221_ FSLLR 226_ EEVRF 231_ GGKKT 236_ QRVCA 241_ PEETT 246_ FHLLH 251_ LSLMR 256_ EYIDY 261_ EFSVL 266_ KEKIT 271_ FKYDI 276_ ERIID 281_ DWILM 286_ GFLVG 291_ NDFIP 296_ HLPHL 301_ HINHD 306_ ALPLL 311_ YGTYV 316_ TILPE 321_ LGGYI 326_ NESGH 331_ LNLPR 336_ FEKYL 341_ VKLSD 346_ FDREH 351_ FSEVF 356_ VDLKW 361_ FESKV 366_ GNKYL 371_ NEAAG 376_ VAAEE 381_ ARNYK 386_ EKKKL 391_ KGQEN 396_ SLCWT 401_ ALDKN 406_ EGEMI 411_ TSKDN 416_ LEDET 421_ EDDDL 426_ FETEF 431_ RQYKR 436_ TYYMT 441_ KMGVD 446_ VVSDD 451_ FLADQ 456_ AACYV 461_ QAIQW 466_ ILHYY 471_ YHGVQ 476_ SWSWY 481_ YPYHY 486_ APFLS 491_ DIHNI 496_ STLKI 501_ HFELG 506_ KPFKP 511_ FEQLL 516_ AVLPA 521_ ASKNL 526_ LPACY 531_ QHLMT 536_ NEDSP 541_ IIEYY 546_ PPDFK 551_ TDLNG 556_ KQQEW 561_ EAVVL 566_ IPFID 571_ EKRLL 576_ EAMET 581_ CNHSL 586_ KKEER 591_ KRNQH 596_ SECLM 601_ CWYDR 606_ DTEFI 611_ YPSPW 616_ PEKFP 621_ AIERC 626_ CTRYK 631_ IISLD 636_ AWRVD 641_ INKNK 646_ ITRID 651_ QKALY 656_ FCGFP 661_ TLKHI 666_ RHKFF 671_ LKKSG 676_ VQVFQ 681_ QSSRG 686_ ENMML 691_ EILVD 696_ AESDE 701_ LTVEN 706_ VASSV 711_ LGKSV 716_ FVNWP 721_ HLEEA 726_ RVVAV 731_ SDGET 736_ KFYLE 741_ EPPGT 746_ QKLYS 751_ GRTAP 756_ PSKVV 761_ HLGDK 766_ EQSNW 771_ AKEVQ 776_ GISEH 781_ YLRRK 786_ GIIIN 791_ ETSAV 796_ VYAQL 801_ LTGRK 806_ YQINQ 811_ NGEVR 816_ LEKQW 821_ SKQVV 826_ PFVYQ 831_ TIVKD 836_ IRAFD 841_ SRFSN 846_ IKTLD 851_ DLFPL 856_ RSMVF 861_ MLGTP 866_ YYGCT 871_ GEVQD 876_ SGDVI 881_ TEGRI 886_ RVIFS 891_ IPCEP 896_ NLDAL 901_ IQNQH 906_ KYSIK 911_ YNPGY 916_ VLASR 921_ LGVSG 926_ YLVSR 931_ FTGSI 936_ FIGRG 941_ SRRNP 946_ HGDHK 951_ ANVGL 956_ NLKFN 961_ KKNEE 966_ VPGYT 971_ KKVGS 976_ EWMYS 981_ SAAEQ 986_ LLAEY 991_ LERAP 996_ ELFSY 1001_ IAKNS 1006_ QEDVF 1011_ YEDDI 1016_ WPGEN 1021_ ENGAE 1026_ KVQEI 1031_ ITWLK 1036_ GHPVS 1041_ TLSRS 1046_ SCDLQ 1051_ ILDAA 1056_ IVEKI 1061_ EEEVE 1066_ KCKQR 1071_ KNNKK 1076_ VRVTV 1081_ KPHLL 1086_ YRPLE 1091_ QQHGV 1096_ IPDRD 1101_ AEFCL 1106_ FDRVV 1111_ NVREN 1116_ FSVPV 1121_ GLRGT 1126_ IIGIK 1131_ GANRE 1136_ ADVLF 1141_ EVLFD 1146_ EEFPG 1151_ GLTIR 1156_ CSPGR 1161_ GYRLP 1166_ TSALV 1171_ NLSHG 1176_ SRSET 1181_ GNQKL 1186_ TAIVK 1191_ PQPAV 1196_ HQHSS 1201_ SSSVS 1206_ SGHLG 1211_ ALNHS 1216_ PQSLF 1221_ VPTQV 1226_ PTKDD 1231_ DEFCN 1236_ IWQSL 1241_ QGSGK 1246_ MQYFQ 1251_ PTIQE 1256_ KGAVL 1261_ PQEIS 1266_ QVNQH 1271_ HKSGF 1276_ NDNSV 1281_ KYQQR 1286_ KHDPH 1291_ RKFKE 1296_ ECKSP 1301_ KAECW 1306_ SQKMS 1311_ NKQPN 1316_ SGIEN 1321_ FLASL 1326_ NISKE 1331_ NEVQS 1336_ SHHGE 1341_ PPSEE 1346_ HLSPQ 1351_ SFAMG 1356_ TRMLK 1361_ EILKI 1366_ DGSNT 1371_ VDHKN 1376_ EIKQI 1381_ ANEIP 1386_ VSSNR 1391_ RDEYG 1396_ LPSQP 1401_ KQNKK 1406_ LASYM 1411_ NKPHS 1416_ ANEYH 1421_ NVQSM 1426_ DNMCW 1431_ PAPSQ 1436_ IPPVS 1441_ TPVTE 1446_ LSRIC 1451_ SLVGM 1456_ PQPDF 1461_ SFLRM 1466_ PQTMT 1471_ VCQVK 1476_ LSNGL 1481_ LVHGP 1486_ QCHSE 1491_ NEAKE 1496_ KAALF 1501_ ALQQL 1506_ GSLGM 1511_ NFPLP 1516_ SQVFA 1521_ NYPSA 1526_ VPPGT 1531_ IPPAF 1536_ PPPTG 1541_ WDHYG 1546_ SNYAL 1551_ GAANI 1556_ MPSSS 1561_ HLFGS 1566_ MPWGP 1571_ SVPVP 1576_ GKPFH 1581_ HTLYS 1586_ GTMPM 1591_ AGGIP 1596_ GGVHN 1601_ QFIPL 1606_ QVTKK 1611_ RVANK 1616_ KNFEN 1621_ KEAQS 1626_ SQATP 1631_ VQTSQ 1636_ PDSSN 1641_ IVKVS 1646_ PRESS 1651_ SASLK 1656_ SSPIA 1661_ QPASS 1666_ FQVET 1671_ ASQGH 1676_ SISHH 1681_ KSTPI 1686_ SSSRR 1691_ KSRKL 1696_ AVNFG 1701_VSKPS
1: Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS)