Interferon lambda-3 (IFN-lambda-3) (Cytokine Zcyto22) (Interleukin-28B) (IL-28B) (Interleukin-28C) (IL-28C)
1_MTGDC 6_ MPVLV 11_ LMAAV 16_ LTVTG 21_ AVPVA 26_ RLRGA 31_ LPDAR 36_ GCHIA 41_ QFKSL 46_ SPQEL 51_ QAFKR 56_ AKDAL 61_ EESLL 66_ LKDCK 71_ CRSRL 76_ FPRTW 81_ DLRQL 86_ QVRER 91_ PVALE 96_ AELAL 101_ TLKVL 106_ EATAD 111_ TDPAL 116_ GDVLD 121_ QPLHT 126_ LHHIL 131_ SQLRA 136_ CIQPQ 141_ PTAGP 146_ RTRGR 151_ LHHWL 156_ HRLQE 161_ APKKE 166_ SPGCL 171_ EASVT 176_ FNLFR 181_ LLTRD 186_ LNCVA 191_SGDLC
1: Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression