Interferon lambda-2 (IFN-lambda-2) (Cytokine Zcyto20) (Interleukin-28A) (IL-28A)
1_MKLDM 6_ TGDCT 11_ PVLVL 16_ MAAVL 21_ TVTGA 26_ VPVAR 31_ LHGAL 36_ PDARG 41_ CHIAQ 46_ FKSLS 51_ PQELQ 56_ AFKRA 61_ KDALE 66_ ESLLL 71_ KDCRC 76_ HSRLF 81_ PRTWD 86_ LRQLQ 91_ VRERP 96_ MALEA 101_ ELALT 106_ LKVLE 111_ ATADT 116_ DPALV 121_ DVLDQ 126_ PLHTL 131_ HHILS 136_ QFRAC 141_ IQPQP 146_ TAGPR 151_ TRGRL 156_ HHWLY 161_ RLQEA 166_ PKKES 171_ PGCLE 176_ ASVTF 181_ NLFRL 186_ LTRDL 191_NCVAS
1: Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression