Mucolipin-2 (Transient receptor potential channel mucolipin 2) (TRPML2)
1_MARQP 6_ YRFPQ 11_ ARIPE 16_ RGSGV 21_ FRLTV 26_ RNAMA 31_ HRDSE 36_ MKEEC 41_ LREDL 46_ KFYFM 51_ SPCEK 56_ YRARR 61_ QIPWK 66_ LGLQI 71_ LKIVM 76_ VTTQL 81_ VRFGL 86_ SNQLV 91_ VAFKE 96_ DNTVA 101_ FKHLF 106_ LKGYS 111_ GTDED 116_ DYSCS 121_ VYTQE 126_ DAYES 131_ IFFAI 136_ NQYHQ 141_ LKDIT 146_ LGTLG 151_ YGENE 156_ DNRIG 161_ LKVCK 166_ QHYKK 171_ GTMFP 176_ SNETL 181_ NIDND 186_ VELDC 191_ VQLDL 196_ QDLSK 201_ KPPDW 206_ KNSSF 211_ FRLEF 216_ YRLLQ 221_ VEISF 226_ HLKGI 231_ DLQTI 236_ HSREL 241_ PDCYV 246_ FQNTI 251_ IFDNK 256_ AHSGK 261_ IKIYF 266_ DSDAK 271_ IEECK 276_ DLNIF 281_ GSTQK 286_ NAQYV 291_ LVFDA 296_ FVIVI 301_ CLASL 306_ ILCTR 311_ SIVLA 316_ LRLRK 321_ RFLNF 326_ FLEKY 331_ KRPVC 336_ DTDQW 341_ EFING 346_ WYVLV 351_ IISDL 356_ MTIIG 361_ SILKM 366_ EIKAK 371_ NLTNY 376_ DLCSI 381_ FLGTS 386_ TLLVW 391_ VGVIR 396_ YLGYF 401_ QAYNV 406_ LILTM 411_ QASLP 416_ KVLRF 421_ CACAG 426_ MIYLG 431_ YTFCG 436_ WIVLG 441_ PYHDK 446_ FENLN 451_ TVAEC 456_ LFSLV 461_ NGDDM 466_ FATFA 471_ QIQQK 476_ SILVW 481_ LFSRL 486_ YLYSF 491_ ISLFI 496_ YMILS 501_ LFIAL 506_ ITDSY 511_ DTIKK 516_ FQQNG 521_ FPETD 526_ LQEFL 531_ KECSS 536_ KEEYQ 541_ KESSA 546_ FLSCI 551_ CCRRR 556_ KRSDD 561_HLIPI
1: Nonselective cation channel probably playing a role in the regulation of membrane trafficking events. Acts as a Ca(2+)-permeable cation channel with inwardly rectifying activity (PubMed:19885840, PubMed:19940139). May activate ARF6 and be involved in the trafficking of GPI-anchored cargo proteins to the cell surface via the ARF6-regulated recycling pathway (PubMed:17662026). May play a role in immune processes. In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells (By similarity). In the innate immune response, may play a role in the regulation of chemokine secretion and macrophage migration (By similarity). Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events (PubMed:19885840). Also functions as a Fe(2+) permeable channel (By similarity)