Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of non-genomic activity of estrogen receptor) (Transcription factor HMX3)
1_MAAAV 6_ LSGPS 11_ AGSAA 16_ GVPGG 21_ TGGLS 26_ AVSSG 31_ PRLRL 36_ LLLES 41_ VSGLL 46_ QPRTG 51_ SAVAP 56_ VHPPN 61_ RSAPH 66_ LPGLM 71_ CLLRL 76_ HGSVG 81_ GAQNL 86_ SALGA 91_ LVSLS 96_ NARLS 101_ SIKTR 106_ FEGLC 111_ LLSLL 116_ VGESP 121_ TELFQ 126_ QHCVS 131_ WLRSI 136_ QQVLQ 141_ TQDPP 146_ ATMEL 151_ AVAVL 156_ RDLLR 161_ YAAQL 166_ PALFR 171_ DISMN 176_ HLPGL 181_ LTSLL 186_ GLRPE 191_ CEQSA 196_ LEGMK 201_ ACMTY 206_ FPRAC 211_ GSLKG 216_ KLASF 221_ FLSRV 226_ DALSP 231_ QLQQL 236_ ACECY 241_ SRLPS 246_ LGAGF 251_ SQGLK 256_ HTESW 261_ EQELH 266_ SLLAS 271_ LHTLL 276_ GALYE 281_ GAETA 286_ PVQNE 291_ GPGVE 296_ MLLSS 301_ EDGDA 306_ HVLLQ 311_ LRQRF 316_ SGLAR 321_ CLGLM 326_ LSSEF 331_ GAPVS 336_ VPVQE 341_ ILDFI 346_ CRTLS 351_ VSSKN 356_ ISLHG 361_ DGPLR 366_ LLLLP 371_ SIHLE 376_ ALDLL 381_ SALIL 386_ ACGSR 391_ LLRFG 396_ ILIGR 401_ LLPQV 406_ LNSWS 411_ IGRDS 416_ LSPGQ 421_ ERPYS 426_ TVRTK 431_ VYAIL 436_ ELWVQ 441_ VCGAS 446_ AGMLQ 451_ GGASG 456_ EALLT 461_ HLLSD 466_ ISPPA 471_ DALKL 476_ RSPRG 481_ SPDGS 486_ LQTGK 491_ PSAPK 496_ KLKLD 501_ VGEAM 506_ APPSH 511_ RKGDS 516_ NANSD 521_ VCAAA 526_ LRGLS 531_ RTILM 536_ CGPLI 541_ KEETH 546_ RRLHD 551_ LVLPL 556_ VMGVQ 561_ QGEVL 566_ GSSPY 571_ TSSRC 576_ RRELY 581_ CLLLA 586_ LLLAP 591_ SPRCP 596_ PPLAC 601_ ALQAF 606_ SLGQR 611_ EDSLE 616_ VSSFC 621_ SEALV 626_ TCAAL 631_ THPRV 636_ PPLQP 641_ MGPTC 646_ PTPAP 651_ VPPPE 656_ APSPF 661_ RAPPF 666_ HPPGP 671_ MPSVG 676_ SMPSA 681_ GPMPS 686_ AGPMP 691_ SAGPV 696_ PSARP 701_ GPPTT 706_ ANHLG 711_ LSVPG 716_ LVSVP 721_ PRLLP 726_ GPENH 731_ RAGSN 736_ EDPIL 741_ APSGT 746_ PPPTI 751_ PPDET 756_ FGGRV 761_ PRPAF 766_ VHYDK 771_ EEASD 776_ VEISL 781_ ESDSD 786_ DSVVI 791_ VPEGL 796_ PPLPP 801_ PPPSG 806_ ATPPP 811_ IAPTG 816_ PPTAS 821_ PPVPA 826_ KEEPE 831_ ELPAA 836_ PGPLP 841_ PPPPP 846_ PPPVP 851_ GPVTL 856_ PPPQL 861_ VPEGT 866_ PGGGG 871_ PPALE 876_ EDLTV 881_ ININS 886_ SDEEE 891_ EEEEE 896_ EEEEE 901_ EEEEE 906_ EEEDF 911_ EEEEE 916_ DEEEY 921_ FEEEE 926_ EEEEE 931_ FEEEF 936_ EEEEG 941_ ELEEE 946_ EEEED 951_ EEEEE 956_ ELEEV 961_ EDLEF 966_ GTAGG 971_ EVEEG 976_ APPPP 981_ TLPPA 986_ LPPPE 991_ SPPKV 996_ QPEPE 1001_ PEPGL 1006_ LLEVE 1011_ EPGTE 1016_ EERGA 1021_ DTAPT 1026_ LAPEA 1031_ LPSQG 1036_ EVERE 1041_ GESPA 1046_ AGPPP 1051_ QELVE 1056_ EEPSA 1061_ PPTLL 1066_ EEETE 1071_ DGSDK 1076_ VQPPP 1081_ ETPAE 1086_ EEMET 1091_ ETEAE 1096_ ALQEK 1101_ EQDDT 1106_ AAMLA 1111_ DFIDC 1116_ PPDDE 1121_KPPPP
1: Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors (PubMed:14963108). Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Functions as the key stabilizing component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit. Regulates pre-60S association of the critical remodeling factor MDN1 (PubMed:21326211). May promote tumorigenesis via its interaction with and modulation of several oncogenes including SRC, PI3K, STAT3 and EGFR. Plays a role in cancer cell metastasis via its ability to modulate E2-mediated cytoskeleton changes and cell migration via its interaction with SRC and PI3K