Cyclin-dependent kinase 20 (EC 2.7.11.22) (CDK-activating kinase p42) (CAK-kinase p42) (Cell cycle-related kinase) (Cell division protein kinase 20) (Cyclin-dependent protein kinase H) (Cyclin-kinase-activating kinase p42)
1_MDQYC 6_ ILGRI 11_ GEGAH 16_ GIVFK 21_ AKHVE 26_ TGEIV 31_ ALKKV 36_ ALRRL 41_ EDGFP 46_ NQALR 51_ EIKAL 56_ QEMED 61_ NQYVV 66_ QLKAV 71_ FPHGG 76_ GFVLA 81_ FEFML 86_ SDLAE 91_ VVRHA 96_ QRPLA 101_ QAQVK 106_ SYLQM 111_ LLKGV 116_ AFCHA 121_ NNIVH 126_ RDLKP 131_ ANLLI 136_ SASGQ 141_ LKIAD 146_ FGLAR 151_ VFSPD 156_ GSRLY 161_ THQVA 166_ TRWYR 171_ APELL 176_ YGARQ 181_ YDQGV 186_ DLWSV 191_ GCIMG 196_ ELLNG 201_ SPLFP 206_ GKNDI 211_ EQLCY 216_ VLRIL 221_ GTPNP 226_ QVWPE 231_ LTELP 236_ DYNKI 241_ SFKEQ 246_ VPMPL 251_ EEVLP 256_ DVSPQ 261_ ALDLL 266_ GQFLL 271_ YPPHQ 276_ RIAAS 281_ KALLH 286_ QYFFT 291_ APLPA 296_ HPSEL 301_ PIPQR 306_ LGGPA 311_ PKAHP 316_ GPPHI 321_ HDFHV 326_ DRPLE 331_ ESLLN 336_ PELIR 341_PFILE
1: Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling (By similarity). Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160'