Adhesion G-protein coupled receptor G2 (G-protein coupled receptor 64) (Human epididymis-specific protein 6) (He6)
1_MVFSV 6_ RQCGH 11_ VGRTE 16_ EVLLT 21_ FKIFL 26_ VIICL 31_ HVVLV 36_ TSLEE 41_ DTDNS 46_ SLSPP 51_ PAKLS 56_ VVSFA 61_ PSSNG 66_ TPEVE 71_ TTSLN 76_ DVTLS 81_ LLPSN 86_ ETEKT 91_ KITIV 96_ KTFNA 101_ SGVKP 106_ QRNIC 111_ NLSSI 116_ CNDSA 121_ FFRGE 126_ IMFQY 131_ DKEST 136_ VPQNQ 141_ HITNG 146_ TLTGV 151_ LSLSE 156_ LKRSE 161_ LNKTL 166_ QTLSE 171_ TYFIM 176_ CATAE 181_ AQSTL 186_ NCTFT 191_ IKLNN 196_ TMNAC 201_ AVIAA 206_ LERVK 211_ IRPME 216_ HCCCS 221_ VRIPC 226_ PSSPE 231_ ELEKL 236_ QCDLQ 241_ DPIVC 246_ LADHP 251_ RGPPF 256_ SSSQS 261_ IPVVP 266_ RATVL 271_ SQVPK 276_ ATSFA 281_ EPPDY 286_ SPVTH 291_ NVPSP 296_ IGEIQ 301_ PLSPQ 306_ PSAPI 311_ ASSPA 316_ IDMPP 321_ QSETI 326_ SSPMP 331_ QTHVS 336_ GTPPP 341_ VKASF 346_ SSPTV 351_ SAPAN 356_ VNTTS 361_ APPVQ 366_ TDIVN 371_ TSSIS 376_ DLENQ 381_ VLQME 386_ KALSL 391_ GSLEP 396_ NLAGE 401_ MINQV 406_ SRLLH 411_ SPPDM 416_ LAPLA 421_ QRLLK 426_ VVDDI 431_ GLQLN 436_ FSNTT 441_ ISLTS 446_ PSLAL 451_ AVIRV 456_ NASSF 461_ NTTTF 466_ VAQDP 471_ ANLQV 476_ SLETQ 481_ APENS 486_ IGTIT 491_ LPSSL 496_ MNNLP 501_ AHDME 506_ LASRV 511_ QFNFF 516_ ETPAL 521_ FQDPS 526_ LENLS 531_ LISYV 536_ ISSSV 541_ ANLTV 546_ RNLTR 551_ NVTVT 556_ LKHIN 561_ PSQDE 566_ LTVRC 571_ VFWDL 576_ GRNGG 581_ RGGWS 586_ DNGCS 591_ VKDRR 596_ LNETI 601_ CTCSH 606_ LTSFG 611_ VLLDL 616_ SRTSV 621_ LPAQM 626_ MALTF 631_ ITYIG 636_ CGLSS 641_ IFLSV 646_ TLVTY 651_ IAFEK 656_ IRRDY 661_ PSKIL 666_ IQLCA 671_ ALLLL 676_ NLVFL 681_ LDSWI 686_ ALYKM 691_ QGLCI 696_ SVAVF 701_ LHYFL 706_ LVSFT 711_ WMGLE 716_ AFHMY 721_ LALVK 726_ VFNTY 731_ IRKYI 736_ LKFCI 741_ VGWGV 746_ PAVVV 751_ TIILT 756_ ISPDN 761_ YGLGS 766_ YGKFP 771_ NGSPD 776_ DFCWI 781_ NNNAV 786_ FYITV 791_ VGYFC 796_ VIFLL 801_ NVSMF 806_ IVVLV 811_ QLCRI 816_ KKKKQ 821_ LGAQR 826_ KTSIQ 831_ DLRSI 836_ AGLTF 841_ LLGIT 846_ WGFAF 851_ FAWGP 856_ VNVTF 861_ MYLFA 866_ IFNTL 871_ QGFFI 876_ FIFYC 881_ VAKEN 886_ VRKQW 891_ RRYLC 896_ CGKLR 901_ LAENS 906_ DWSKT 911_ ATNGL 916_ KKQTV 921_ NQGVS 926_ SSSNS 931_ LQSSS 936_ NSTNS 941_ TTLLV 946_ NNDCS 951_ VHASG 956_ NGNAS 961_ TERNG 966_ VSFSV 971_ QNGDV 976_ CLHDF 981_ TGKQH 986_ MFNEK 991_ EDSCN 996_ GKGRM 1001_ ALRRT 1006_ SKRGS 1011_LHFIE
1: Adhesion G-protein coupled receptor (aGPCR) for steroid hormones, such as dehydroepiandrosterone (DHEA; also named 3beta-hydroxyandrost-5-en-17-one) and androstenedione (PubMed:29393851, PubMed:35982227, PubMed:39884271). Involved in a signal transduction pathway controlling epididymal function and male fertility (PubMed:29393851). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:33303626, PubMed:34234254). ADGRG2 is coupled to G(s) G proteins and mediates activation of adenylate cyclase activity (PubMed:29393851, PubMed:34234254). Also able to couple with G(q) G proteins in vitro (PubMed:29393851). Together with CFTR, required to promote fluid reabsorption within efferent ductule (PubMed:29393851)