WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy)
1_MNMVK 6_ RIMGR 11_ PRQEE 16_ CSPQD 21_ NALGL 26_ MHLRR 31_ LFTEL 36_ CHPPR 41_ HMTQK 46_ EQEEK 51_ LYMML 56_ PVFNR 61_ VFGNA 66_ PPNTM 71_ TEKFS 76_ DLLQF 81_ TTQVS 86_ RLMVT 91_ EIRRR 96_ ASNKS 101_ TEAAS 106_ RAIVQ 111_ FLEIN 116_ QSEEA 121_ SRGWM 126_ LLTTI 131_ NLLAS 136_ SGQKT 141_ VDCMT 146_ TMSVP 151_ STLVK 156_ CLYLF 161_ FDLPH 166_ VPEAV 171_ GGAQN 176_ ELPLA 181_ ERRGL 186_ LQKVF 191_ VQILV 196_ KLCSF 201_ VSPAE 206_ ELAQK 211_ DDLQL 216_ LFSAI 221_ TSWCP 226_ PYNLP 231_ WRKSA 236_ GEVLM 241_ TISRH 246_ GLSVN 251_ VVKYI 256_ HEKEC 261_ LSTCV 266_ QNMQQ 271_ SDDLS 276_ PLEIV 281_ EMFAG 286_ LSCFL 291_ KDSSD 296_ VSQTL 301_ LDDFR 306_ IWQGY 311_ NFLCD 316_ LLLRL 321_ EQAKE 326_ AESKD 331_ ALKDL 336_ VNLIT 341_ SLTTY 346_ GVSEL 351_ KPAGI 356_ TTGAP 361_ FLLPG 366_ FAVPQ 371_ PAGKG 376_ HSVRN 381_ VQAFA 386_ VLQNA 391_ FLKAK 396_ TSFLA 401_ QIILD 406_ AITNI 411_ YMADN 416_ ANYFI 421_ LESQH 426_ TLSQF 431_ AEKIS 436_ KLPEV 441_ QNKYF 446_ EMLEF 451_ VVFSL 456_ NYIPC 461_ KELIS 466_ VSILL 471_ KSSSS 476_ YHCSI 481_ IAMKT 486_ LLKFT 491_ RHDYI 496_ FKDVF 501_ REVGL 506_ LEVMV 511_ NLLHK 516_ YAALL 521_ KDPTQ 526_ ALNEQ 531_ GDSRN 536_ NSSVE 541_ DQKHL 546_ ALLVM 551_ ETLTV 556_ LLQGS 561_ NTNAG 566_ IFREF 571_ GGARC 576_ AHNIV 581_ KYPQC 586_ RQHAL 591_ MTIQQ 596_ LVLSP 601_ NGDDD 606_ MGTLL 611_ GLMHS 616_ APPTE 621_ LQLKT 626_ DILRA 631_ LLSVL 636_ RESHR 641_ SRTVF 646_ RKVGG 651_ FVYIT 656_ SLLVA 661_ MERSL 666_ SCPPK 671_ NGWEK 676_ VNQNQ 681_ VFELL 686_ HTVFC 691_ TLTAA 696_ MRYEP 701_ ANSHF 706_ FKTEI 711_ QYEKL 716_ ADAVR 721_ FLGCF 726_ SDLRK 731_ ISAMN 736_ VFPSN 741_ TQPFQ 746_ RLLEE 751_ DVISI 756_ ESVSP 761_ TLRHC 766_ SKLFI 771_ YLYKV 776_ ATDSF 781_ DSRAE 786_ QIPPC 791_ LTSES 796_ SLPSP 801_ WGTPA 806_ LSRKR 811_ HAYHS 816_ VSTPP 821_ VYPPK 826_ NVADL 831_ KLHVT 836_ TSSLQ 841_ SSDAV 846_ IIHPG 851_ AMLAM 856_ LDLLA 861_ SVGSV 866_ TQPEH 871_ ALDLQ 876_ LAVAN 881_ ILQSL 886_ VHTER 891_ NQQVM 896_ CEAGL 901_ HARLL 906_ QRCSA 911_ ALADE 916_ DHSLH 921_ PPLQR 926_ MFERL 931_ ASQAL 936_ EPMVL 941_ REFLR 946_ LASPL 951_ NCGAW 956_ DKKLL 961_ KQYRV 966_ HKPSS 971_ LSYEP 976_ EMRSS 981_ MITSL 986_ EGLGT 991_ DNVFS 996_ LHEDN 1001_ HYRIS 1006_ KSLVK 1011_ SAEGS 1016_ TVPLT 1021_ RVKCL 1026_ VSMTT 1031_ PHDIR 1036_ LHGSS 1041_ VTPAF 1046_ VEFDT 1051_ SLEGF 1056_ GCLFL 1061_ PSLAP 1066_ HNAPT 1071_ NNTVT 1076_ TGLID 1081_ GAVVS 1086_ GIGSG 1091_ ERFFP 1096_ PPSGL 1101_ SYSSW 1106_ FCIEH 1111_ FSSPP 1116_ NNHPV 1121_ RLLTV 1126_ VRRAN 1131_ SSEQH 1136_ YVCLA 1141_ IVLSA 1146_ KDRSL 1151_ IVSTK 1156_ EELLQ 1161_ NYVDD 1166_ FSEES 1171_ SFYEI 1176_ LPCCA 1181_ RFRCG 1186_ ELIIE 1191_ GQWHH 1196_ LVLVM 1201_ SKGML 1206_ KNSTA 1211_ ALYID 1216_ GQLVN 1221_ TVKLH 1226_ YVHST 1231_ PGGSG 1236_ SANPP 1241_ VVSTV 1246_ YAYIG 1251_ TPPAQ 1256_ RQIAS 1261_ LVWRL 1266_ GPTHF 1271_ LEEVL 1276_ PSSNV 1281_ TTIYE 1286_ LGPNY 1291_ VGSFQ 1296_ AVCMP 1301_ CKDAK 1306_ SEGVV 1311_ PSPVS 1316_ LVPEE 1321_ KVSFG 1326_ LYALS 1331_ VSSLT 1336_ VARIR 1341_ KVYNK 1346_ LDSKA 1351_ IAKQL 1356_ GISSH 1361_ ENATP 1366_ VKLIH 1371_ NSAGH 1376_ LNGSA 1381_ RTIGA 1386_ ALIGY 1391_ LGVRT 1396_ FVPKP 1401_ VATTL 1406_ QYVGG 1411_ AAAIL 1416_ GLVAM 1421_ ASDVE 1426_ GLYAA 1431_ VKALV 1436_ CVVKS 1441_ NPLAS 1446_ KEMER 1451_ IKGYQ 1456_ LLAML 1461_ LKKKR 1466_ SLLNS 1471_ HILHL 1476_ TFSLV 1481_ GTVDS 1486_ GHETS 1491_ IIPNS 1496_ TAFQD 1501_ LLCDF 1506_ EVWLH 1511_ APYEL 1516_ HLSLF 1521_ EHFIE 1526_ LLTES 1531_ SEASK 1536_ NAKLM 1541_ REFQL 1546_ IPKLL 1551_ LTLRD 1556_ MSLSQ 1561_ PTIAA 1566_ ISNVL 1571_ SFLLQ 1576_ GFPSS 1581_ NDLLR 1586_ FGQFI 1591_ SSTLP 1596_ TFAVC 1601_ EKFVV 1606_ MEINN 1611_ EEKLD 1616_ TGTEE 1621_ EFGGL 1626_ VSANL 1631_ ILLRN 1636_ RLLDI 1641_ LLKLI 1646_ YTSKE 1651_ KTSIN 1656_ LQACE 1661_ ELVKT 1666_ LGFDW 1671_ IMMFM 1676_ EEHLH 1681_ STTVT 1686_ AAMRI 1691_ LVVLL 1696_ SNQSI 1701_ LIKFK 1706_ EGLSG 1711_ GGWLE 1716_ QTDSV 1721_ LTNKI 1726_ GTVLG 1731_ FNVGR 1736_ SAGGR 1741_ STVRE 1746_ INRDA 1751_ CHFPG 1756_ FPVLQ 1761_ SFLPK 1766_ HTNVP 1771_ ALYFL 1776_ LMALF 1781_ LQQPV 1786_ SELPE 1791_ NLQVS 1796_ VPVIS 1801_ CRSKQ 1806_ GCQFD 1811_ LDSIW 1816_ TFIFG 1821_ VPASS 1826_ GTVVS 1831_ SIHNV 1836_ CTEAV 1841_ FLLLG 1846_ MLRSM 1851_ LTSPW 1856_ QSEEE 1861_ GSWLR 1866_ EYPVT 1871_ LMQFF 1876_ RYLYH 1881_ NVPDL 1886_ ASMWM 1891_ SPDFL 1896_ CALAA 1901_ TVFPF 1906_ NIRPY 1911_ SEMVT 1916_ DLDDE 1921_ VGSPA 1926_ EEFKA 1931_ FAADT 1936_ GMNRS 1941_ QSEYC 1946_ NVGTK 1951_ TYLTN 1956_ HPAKK 1961_ FVFDF 1966_ MRVLI 1971_ IDNLC 1976_ LTPAS 1981_ KQTPL 1986_ IDLLL 1991_ EASPE 1996_ RSTRT 2001_ QQKEF 2006_ QTYIL 2011_ DSVMD 2016_ HLLAA 2021_ DVLLG 2026_ EDASL 2031_ PITSG 2036_ GSYQV 2041_ LVNNV 2046_ FYFTQ 2051_ RVVDK 2056_ LWQGM 2061_ FNKES 2066_ KLLID 2071_ FIIQL 2076_ IAQSK 2081_ RRSQG 2086_ LSLDA 2091_ VYHCL 2096_ NRTIL 2101_ YQFSR 2106_ AHKTV 2111_ PQQVA 2116_ LLDSL 2121_ RVLTV 2126_ NRNLI 2131_ LGPGN 2136_ HDQEF 2141_ ISCLA 2146_ HCLIN 2151_ LHVGS 2156_ NVDGF 2161_ GLEAE 2166_ ARMTT 2171_ WHIMI 2176_ PSDIE 2181_ PDGSY 2186_ SQDIS 2191_ EGRQL 2196_ LIKAV 2201_ NRVWT 2206_ ELIHS 2211_ KKQVL 2216_ EELFK 2221_ VTLPV 2226_ NERGH 2231_ VDIAT 2236_ ARPLI 2241_ EEAAL 2246_ KCWQN 2251_ HLAHE 2256_ KKCIS 2261_ RGEAL 2266_ APTTQ 2271_ SKLSR 2276_ VSSGF 2281_ GLSKL 2286_ TGSRR 2291_ NRKES 2296_ GLNKH 2301_ SLSTQ 2306_ EISQW 2311_ MFTHI 2316_ AVVRD 2321_ LVDTQ 2326_ YKEYQ 2331_ ERQQN 2336_ ALKYV 2341_ TEEWC 2346_ QIECE 2351_ LLRER 2356_ GLWGP 2361_ PIGSH 2366_ LDKWM 2371_ LEMTE 2376_ GPCRM 2381_ RKKMV 2386_ RNDMF 2391_ YNHYP 2396_ YVPET 2401_ EQETN 2406_ VASEI 2411_ PSKQP 2416_ ETPDD 2421_ IPQKK 2426_ PARYR 2431_ RAVSY 2436_ DSKEY 2441_ YMRLA 2446_ SGNPA 2451_ IVQDA 2456_ IVESS 2461_ EGEAA 2466_ QQEPE 2471_ HGEDT 2476_ IAKVK 2481_ GLVKP 2486_ PLKRS 2491_ RSAPD 2496_ GGDEE 2501_ NQEQL 2506_ QDQIA 2511_ EGSSI 2516_ EEEEK 2521_ TDNAT 2526_ LLRLL 2531_ EEGEK 2536_ IQHMY 2541_ RCARV 2546_ QGLDT 2551_ SEGLL 2556_ LFGKE 2561_ HFYVI 2566_ DGFTM 2571_ TATRE 2576_ IRDIE 2581_ TLPPN 2586_ MHEPI 2591_ IPRGA 2596_ RQGPS 2601_ QLKRT 2606_ CSIFA 2611_ YEDIK 2616_ EVHKR 2621_ RYLLQ 2626_ PIAVE 2631_ VFSGD 2636_ GRNYL 2641_ LAFQK 2646_ GIRNK 2651_ VYQRF 2656_ LAVVP 2661_ SLTDS 2666_ SESVS 2671_ GQRPN 2676_ TSVEQ 2681_ GSGLL 2686_ STLVG 2691_ EKSVT 2696_ QRWER 2701_ GEISN 2706_ FQYLM 2711_ HLNTL 2716_ AGRSY 2721_ NDLMQ 2726_ YPVFP 2731_ WILAD 2736_ YDSEE 2741_ VDLTN 2746_ PKTFR 2751_ NLAKP 2756_ MGAQT 2761_ DERLA 2766_ QYKKR 2771_ YKDWE 2776_ DPNGE 2781_ TPAYH 2786_ YGTHY 2791_ SSAMI 2796_ VASYL 2801_ VRMEP 2806_ FTQIF 2811_ LRLQG 2816_ GHFDL 2821_ ADRMF 2826_ HSVRE 2831_ AWYSA 2836_ SKHNM 2841_ ADVKE 2846_ LIPEF 2851_ FYLPE 2856_ FLFNS 2861_ NNFDL 2866_ GCKQN 2871_ GTKLG 2876_ DVILP 2881_ PWAKG 2886_ DPREF 2891_ IRVHR 2896_ EALEC 2901_ DYVSA 2906_ HLHEW 2911_ IDLIF 2916_ GYKQQ 2921_ GPAAV 2926_ EAVNV 2931_ FHHLF 2936_ YEGQV 2941_ DIYNI 2946_ NDPLK 2951_ ETATI 2956_ GFINN 2961_ FGQIP 2966_ KQLFK 2971_ KPHPP 2976_ KRVRS 2981_ RLNGD 2986_ NAGIS 2991_ VLPGS 2996_ TSDKI 3001_ FFHHL 3006_ DNLRP 3011_ SLTPV 3016_ KELKE 3021_ PVGQI 3026_ VCTDK 3031_ GILAV 3036_ EQNKV 3041_ LIPPT 3046_ WNKTF 3051_ AWGYA 3056_ DLSCR 3061_ LGTYE 3066_ SDKAM 3071_ TVYEC 3076_ LSEWG 3081_ QILCA 3086_ ICPNP 3091_ KLVIT 3096_ GGTST 3101_ VVCVW 3106_ EMGTS 3111_ KEKAK 3116_ TVTLK 3121_ QALLG 3126_ HTDTV 3131_ TCATA 3136_ SLAYH 3141_ IIVSG 3146_ SRDRT 3151_ CIIWD 3156_ LNKLS 3161_ FLTQL 3166_ RGHRA 3171_ PVSAL 3176_ CINEL 3181_ TGDIV 3186_ SCAGT 3191_ YIHVW 3196_ SINGN 3201_ PIVSV 3206_ NTFTG 3211_ RSQQI 3216_ ICCCM 3221_ SEMNE 3226_ WDTQN 3231_ VIVTG 3236_ HSDGV 3241_ VRFWR 3246_ MEFLQ 3251_ VPETP 3256_ APEPA 3261_ EVLEM 3266_ QEDCP 3271_ EAQIG 3276_ QEAQD 3281_ EDSSD 3286_ SEADE 3291_ QSISQ 3296_ DPKDT 3301_ PSQPS 3306_ STSHR 3311_ PRAAS 3316_ CRATA 3321_ AWCTD 3326_ SGSDD 3331_ SRRWS 3336_ DQLSL 3341_ DEKDG 3346_ FIFVN 3351_ YSEGQ 3356_ TRAHL 3361_ QGPLS 3366_ HPHPN 3371_ PIEVR 3376_ NYSRL 3381_ KPGYR 3386_ WERQL 3391_ VFRSK 3396_ LTMHT 3401_ AFDRK 3406_ DNAHP 3411_ AEVTA 3416_ LGISK 3421_ DHSRI 3426_ LVGDS 3431_ RGRVF 3436_ SWSVS 3441_ DQPGR 3446_ SAADH 3451_ WVKDE 3456_ GGDSC 3461_ SGCSV 3466_ RFSLT 3471_ ERRHH 3476_ CRNCG 3481_ QLFCQ 3486_ KCSRF 3491_ QSEIK 3496_ RLKIS 3501_ SPVRV 3506_ CQNCY 3511_ YNLQH 3516_ ERGSE 3521_DGPRN
1: Required for selective macroautophagy (aggrephagy). Acts as an adapter protein by linking specific proteins destined for degradation to the core autophagic machinery members, such as the ATG5-ATG12-ATG16L E3-like ligase, SQSTM1 and LC3 (PubMed:20417604). Along with p62/SQSTM1, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures). Along with SQSTM1, required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Important for normal brain development. Essential for the formation of axonal tracts throughout the brain and spinal cord, including the formation of the major forebrain commissures. Involved in the ability of neural cells to respond to guidance cues. Required for cortical neurons to respond to the trophic effects of netrin-1/NTN1 (By similarity). Regulates Wnt signaling through the removal of DVL3 aggregates, likely in an autophagy-dependent manner. This process may be important for the determination of brain size during embryonic development (PubMed:27008544). May regulate osteoclastogenesis by acting on the TNFSF11/RANKL - TRAF6 pathway (By similarity). After cytokinetic abscission, involved in midbody remnant degradation (PubMed:24128730). In vitro strongly binds to phosphatidylinositol 3-phosphate (PtdIns3P) (PubMed:15292400)