Gene name: CMTM4

Uniprot entry:

Q8IZR5

Protein names:

CKLF-like MARVEL transmembrane domain-containing protein 4 (Chemokine-like factor superfamily member 4)

Protein sequence:

1_MRSGE 6_ ELDGF 11_ EGEAS 16_ STSMI 21_ SGASS 26_ PYQPT 31_ TEPVS 36_ QRRGL 41_ AGLRC 46_ DPDYL 51_ RGALG 56_ RLKVA 61_ QVILA 66_ LIAFI 71_ CIETI 76_ MACSP 81_ CEGLY 86_ FFEFV 91_ SCSAF 96_ VVTGV 101_ LLIMF 106_ SLNLH 111_ MRIPQ 116_ INWNL 121_ TDLVN 126_ TGLSA 131_ FLFFI 136_ ASIVL 141_ AALNH 146_ RAGAE 151_ IAAVI 156_ FGFLA 161_ TAAYA 166_ VNTFL 171_ AVQKW 176_ RVSVR 181_ QQSTN 186_ DYIRA 191_ RTESR 196_ DVDSR 201_ PEIQR 206_ LDTFS 211_ YSTNV 216_ TVRKK 221_ SPTNL 226_LSLNH

Protein annotations

Protein functions:

1: Acts as a backup for CMTM6 to regulate plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. May protect PD-L1/CD274 from being polyubiquitinated and targeted for degradation