Heparan sulfate glucosamine 3-O-sulfotransferase 5 (EC 2.8.2.23) (Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 5) (3-OST-5) (Heparan sulfate 3-O-sulfotransferase 5) (h3-OST-5)
1_MLFKQ 6_ QAWLR 11_ QKLLV 16_ LGSLA 21_ VGSLL 26_ YLVAR 31_ VGSLD 36_ RLQPI 41_ CPIEG 46_ RLGGA 51_ RTQAE 56_ FPLRA 61_ LQFKR 66_ GLLHE 71_ FRKGN 76_ ASKEQ 81_ VRLHD 86_ LVQQL 91_ PKAII 96_ IGVRK 101_ GGTRA 106_ LLEML 111_ NLHPA 116_ VVKAS 121_ QEIHF 126_ FDNDE 131_ NYGKG 136_ IEWYR 141_ KKMPF 146_ SYPQQ 151_ ITIEK 156_ SPAYF 161_ ITEEV 166_ PERIY 171_ KMNSS 176_ IKLLI 181_ IVREP 186_ TTRAI 191_ SDYTQ 196_ VLEGK 201_ ERKNK 206_ TYYKF 211_ EKLAI 216_ DPNTC 221_ EVNTK 226_ YKAVR 231_ TSIYT 236_ KHLER 241_ WLKYF 246_ PIEQF 251_ HVVDG 256_ DRLIT 261_ EPLPE 266_ LQLVE 271_ KFLNL 276_ PPRIS 281_ QYNLY 286_ FNATR 291_ GFYCL 296_ RFNII 301_ FNKCL 306_ AGSKG 311_ RIHPE 316_ VDPSV 321_ ITKLR 326_ KFFHP 331_ FNQKF 336_ YQITG 341_RTLNW
1: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site. Also generates GlcUA-GlcNS or IdoUA-GlcNS and IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry