Tensin-4 (C-terminal tensin-like protein)
1_MSQVM 6_ SSPLL 11_ AGGHA 16_ VSLAP 21_ CDEPR 26_ RTLHP 31_ APSPS 36_ LPPQC 41_ SYYTT 46_ EGWGA 51_ QALMA 56_ PVPCM 61_ GPPGR 66_ LQQAP 71_ QVEAK 76_ ATCFL 81_ PSPGE 86_ KALGT 91_ PEDLD 96_ SYIDF 101_ SLESL 106_ NQMIL 111_ ELDPT 116_ FQLLP 121_ PGTGG 126_ SQAEL 131_ AQSTM 136_ SMRKK 141_ EESEA 146_ LDIKY 151_ IEVTS 156_ ARSRC 161_ HDGPQ 166_ HCSSP 171_ SVTPP 176_ FGSLR 181_ SGGLL 186_ LSRDV 191_ PRETR 196_ SSSES 201_ LIFSG 206_ NQGRG 211_ HQRPL 216_ PPSEG 221_ LSPRP 226_ PNSPS 231_ ISIPC 236_ MGSKA 241_ SSPHG 246_ LGSPL 251_ VASPR 256_ LEKRL 261_ GGLAP 266_ QRGSR 271_ ISVLS 276_ ASPVS 281_ DVSYM 286_ FGSSQ 291_ SLLHS 296_ SNSSH 301_ QSSSR 306_ SLESP 311_ ANSSS 316_ SLHSL 321_ GSVSL 326_ CTRPS 331_ DFQAP 336_ RNPTL 341_ TMGQP 346_ RTPHS 351_ PPLAK 356_ EHASS 361_ CPPSI 366_ TNSMV 371_ DIPIV 376_ LINGC 381_ PEPGS 386_ SPPQR 391_ TPGHQ 396_ NSVQP 401_ GAASP 406_ SNPCP 411_ ATRSN 416_ SQTLS 421_ DAPFT 426_ TCPEG 431_ PARDM 436_ QPTMK 441_ FVMDT 446_ SKYWF 451_ KPNIT 456_ REQAI 461_ ELLRK 466_ EEPGA 471_ FVIRD 476_ SSSYR 481_ GSFGL 486_ ALKVQ 491_ EVPAS 496_ AQSRP 501_ GEDSN 506_ DLIRH 511_ FLIES 516_ SAKGV 521_ HLKGA 526_ DEEPY 531_ FGSLS 536_ AFVCQ 541_ HSIMA 546_ LALPC 551_ KLTIP 556_ QRELG 561_ GADGA 566_ SDSTD 571_ SPASC 576_ QKKSA 581_ GCHTL 586_ YLSSV 591_ SVETL 596_ TGALA 601_ VQKAI 606_ STTFE 611_ RDILP 616_ TPTVV 621_ HFKVT 626_ EQGIT 631_ LTDVQ 636_ RKVFF 641_ RRHYP 646_ LTTLR 651_ FCGMD 656_ PEQRK 661_ WQKYC 666_ KPSWI 671_ FGFVA 676_ KSQTE 681_ PQENV 686_ CHLFA 691_ EYDMV 696_ QPASQ 701_ VIGLV 706_TALLQ
1: Promotes EGF-induced cell migration by displacing tensin TNS3 from the cytoplasmic tail of integrin ITGB1 which results in dissociation of TNS3 from focal adhesions, disassembly of actin stress fibers and initiation of cell migration (PubMed:17643115). Suppresses ligand-induced degradation of EGFR by reducing EGFR ubiquitination in the presence of EGF (PubMed:23774213). Increases MET protein stability by inhibiting MET endocytosis and subsequent lysosomal degradation which leads to increased cell survival, proliferation and migration (PubMed:24814316)