Phospholipid-transporting ATPase ABCA7 (EC 7.6.2.1) (ABCA-SSN) (ATP-binding cassette sub-family A member 7) (Autoantigen SS-N) (Macrophage ABC transporter)
1_MAFWT 6_ QLMLL 11_ LWKNF 16_ MYRRR 21_ QPVQL 26_ LVELL 31_ WPLFL 36_ FFILV 41_ AVRHS 46_ HPPLE 51_ HHECH 56_ FPNKP 61_ LPSAG 66_ TVPWL 71_ QGLIC 76_ NVNNT 81_ CFPQL 86_ TPGEE 91_ PGRLS 96_ NFNDS 101_ LVSRL 106_ LADAR 111_ TVLGG 116_ ASAHR 121_ TLAGL 126_ GKLIA 131_ TLRAA 136_ RSTAQ 141_ PQPTK 146_ QSPLE 151_ PPMLD 156_ VAELL 161_ TSLLR 166_ TESLG 171_ LALGQ 176_ AQEPL 181_ HSLLE 186_ AAEDL 191_ AQELL 196_ ALRSL 201_ VELRA 206_ LLQRP 211_ RGTSG 216_ PLELL 221_ SEALC 226_ SVRGP 231_ SSTVG 236_ PSLNW 241_ YEASD 246_ LMELV 251_ GQEPE 256_ SALPD 261_ SSLSP 266_ ACSEL 271_ IGALD 276_ SHPLS 281_ RLLWR 286_ RLKPL 291_ ILGKL 296_ LFAPD 301_ TPFTR 306_ KLMAQ 311_ VNRTF 316_ EELTL 321_ LRDVR 326_ EVWEM 331_ LGPRI 336_ FTFMN 341_ DSSNV 346_ AMLQR 351_ LLQMQ 356_ DEGRR 361_ QPRPG 366_ GRDHM 371_ EALRS 376_ FLDPG 381_ SGGYS 386_ WQDAH 391_ ADVGH 396_ LVGTL 401_ GRVTE 406_ CLSLD 411_ KLEAA 416_ PSEAA 421_ LVSRA 426_ LQLLA 431_ EHRFW 436_ AGVVF 441_ LGPED 446_ SSDPT 451_ EHPTP 456_ DLGPG 461_ HVRIK 466_ IRMDI 471_ DVVTR 476_ TNKIR 481_ DRFWD 486_ PGPAA 491_ DPLTD 496_ LRYVW 501_ GGFVY 506_ LQDLV 511_ ERAAV 516_ RVLSG 521_ ANPRA 526_ GLYLQ 531_ QMPYP 536_ CYVDD 541_ VFLRV 546_ LSRSL 551_ PLFLT 556_ LAWIY 561_ SVTLT 566_ VKAVV 571_ REKET 576_ RLRDT 581_ MRAMG 586_ LSRAV 591_ LWLGW 596_ FLSCL 601_ GPFLL 606_ SAALL 611_ VLVLK 616_ LGDIL 621_ PYSHP 626_ GVVFL 631_ FLAAF 636_ AVATV 641_ TQSFL 646_ LSAFF 651_ SRANL 656_ AAACG 661_ GLAYF 666_ SLYLP 671_ YVLCV 676_ AWRDR 681_ LPAGG 686_ RVAAS 691_ LLSPV 696_ AFGFG 701_ CESLA 706_ LLEEQ 711_ GEGAQ 716_ WHNVG 721_ TRPTA 726_ DVFSL 731_ AQVSG 736_ LLLLD 741_ AALYG 746_ LATWY 751_ LEAVC 756_ PGQYG 761_ IPEPW 766_ NFPFR 771_ RSYWC 776_ GPRPP 781_ KSPAP 786_ CPTPL 791_ DPKVL 796_ VEEAP 801_ PGLSP 806_ GVSVR 811_ SLEKR 816_ FPGSP 821_ QPALR 826_ GLSLD 831_ FYQGH 836_ ITAFL 841_ GHNGA 846_ GKTTT 851_ LSILS 856_ GLFPP 861_ SGGSA 866_ FILGH 871_ DVRSS 876_ MAAIR 881_ PHLGV 886_ CPQYN 891_ VLFDM 896_ LTVDE 901_ HVWFY 906_ GRLKG 911_ LSAAV 916_ VGPEQ 921_ DRLLQ 926_ DVGLV 931_ SKQSV 936_ QTRHL 941_ SGGMQ 946_ RKLSV 951_ AIAFV 956_ GGSQV 961_ VILDE 966_ PTAGV 971_ DPASR 976_ RGIWE 981_ LLLKY 986_ REGRT 991_ LILST 996_ HHLDE 1001_ AELLG 1006_ DRVAV 1011_ VAGGR 1016_ LCCCG 1021_ SPLFL 1026_ RRHLG 1031_ SGYYL 1036_ TLVKA 1041_ RLPLT 1046_ TNEKA 1051_ DTDME 1056_ GSVDT 1061_ RQEKK 1066_ NGSQG 1071_ SRVGT 1076_ PQLLA 1081_ LVQHW 1086_ VPGAR 1091_ LVEEL 1096_ PHELV 1101_ LVLPY 1106_ TGAHD 1111_ GSFAT 1116_ LFREL 1121_ DTRLA 1126_ ELRLT 1131_ GYGIS 1136_ DTSLE 1141_ EIFLK 1146_ VVEEC 1151_ AADTD 1156_ MEDGS 1161_ CGQHL 1166_ CTGIA 1171_ GLDVT 1176_ LRLKM 1181_ PPQET 1186_ ALENG 1191_ EPAGS 1196_ APETD 1201_ QGSGP 1206_ DAVGR 1211_ VQGWA 1216_ LTRQQ 1221_ LQALL 1226_ LKRFL 1231_ LARRS 1236_ RRGLF 1241_ AQIVL 1246_ PALFV 1251_ GLALV 1256_ FSLIV 1261_ PPFGH 1266_ YPALR 1271_ LSPTM 1276_ YGAQV 1281_ SFFSE 1286_ DAPGD 1291_ PGRAR 1296_ LLEAL 1301_ LQEAG 1306_ LEEPP 1311_ VQHSS 1316_ HRFSA 1321_ PEVPA 1326_ EVAKV 1331_ LASGN 1336_ WTPES 1341_ PSPAC 1346_ QCSRP 1351_ GARRL 1356_ LPDCP 1361_ AAAGG 1366_ PPPPQ 1371_ AVTGS 1376_ GEVVQ 1381_ NLTGR 1386_ NLSDF 1391_ LVKTY 1396_ PRLVR 1401_ QGLKT 1406_ KKWVN 1411_ EVRYG 1416_ GFSLG 1421_ GRDPG 1426_ LPSGQ 1431_ ELGRS 1436_ VEELW 1441_ ALLSP 1446_ LPGGA 1451_ LDRVL 1456_ KNLTA 1461_ WAHSL 1466_ DAQDS 1471_ LKIWF 1476_ NNKGW 1481_ HSMVA 1486_ FVNRA 1491_ SNAIL 1496_ RAHLP 1501_ PGPAR 1506_ HAHSI 1511_ TTLNH 1516_ PLNLT 1521_ KEQLS 1526_ EGALM 1531_ ASSVD 1536_ VLVSI 1541_ CVVFA 1546_ MSFVP 1551_ ASFTL 1556_ VLIEE 1561_ RVTRA 1566_ KHLQL 1571_ MGGLS 1576_ PTLYW 1581_ LGNFL 1586_ WDMCN 1591_ YLVPA 1596_ CIVVL 1601_ IFLAF 1606_ QQRAY 1611_ VAPAN 1616_ LPALL 1621_ LLLLL 1626_ YGWSI 1631_ TPLMY 1636_ PASFF 1641_ FSVPS 1646_ TAYVV 1651_ LTCIN 1656_ LFIGI 1661_ NGSMA 1666_ TFVLE 1671_ LFSDQ 1676_ KLQEV 1681_ SRILK 1686_ QVFLI 1691_ FPHFC 1696_ LGRGL 1701_ IDMVR 1706_ NQAMA 1711_ DAFER 1716_ LGDRQ 1721_ FQSPL 1726_ RWEVV 1731_ GKNLL 1736_ AMVIQ 1741_ GPLFL 1746_ LFTLL 1751_ LQHRS 1756_ QLLPQ 1761_ PRVRS 1766_ LPLLG 1771_ EEDED 1776_ VARER 1781_ ERVVQ 1786_ GATQG 1791_ DVLVL 1796_ RNLTK 1801_ VYRGQ 1806_ RMPAV 1811_ DRLCL 1816_ GIPPG 1821_ ECFGL 1826_ LGVNG 1831_ AGKTS 1836_ TFRMV 1841_ TGDTL 1846_ ASRGE 1851_ AVLAG 1856_ HSVAR 1861_ EPSAA 1866_ HLSMG 1871_ YCPQS 1876_ DAIFE 1881_ LLTGR 1886_ EHLEL 1891_ LARLR 1896_ GVPEA 1901_ QVAQT 1906_ AGSGL 1911_ ARLGL 1916_ SWYAD 1921_ RPAGT 1926_ YSGGN 1931_ KRKLA 1936_ TALAL 1941_ VGDPA 1946_ VVFLD 1951_ EPTTG 1956_ MDPSA 1961_ RRFLW 1966_ NSLLA 1971_ VVREG 1976_ RSVML 1981_ TSHSM 1986_ EECEA 1991_ LCSRL 1996_ AIMVN 2001_ GRFRC 2006_ LGSPQ 2011_ HLKGR 2016_ FAAGH 2021_ TLTLR 2026_ VPAAR 2031_ SQPAA 2036_ AFVAA 2041_ EFPGA 2046_ ELREA 2051_ HGGRL 2056_ RFQLP 2061_ PGGRC 2066_ ALARV 2071_ FGELA 2076_ VHGAE 2081_ HGVED 2086_ FSVSQ 2091_ TMLEE 2096_ VFLYF 2101_ SKDQG 2106_ KDEDT 2111_ EEQKE 2116_ AGVGV 2121_ DPAPG 2126_ LQHPK 2131_ RVSQF 2136_ LDDPS 2141_TAETV
1: Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP (PubMed:24097981). Transports preferentially phosphatidylserine over phosphatidylcholine (PubMed:24097981). Plays a role in lipid homeostasis and macrophage-mediated phagocytosis (PubMed:12917409, PubMed:12925201, PubMed:14570867, PubMed:14592415). Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells (PubMed:12917409, PubMed:14570867, PubMed:14592415). May also mediate cholesterol efflux (PubMed:14570867). May regulate cellular ceramide homeostasis during keratinocyte differentiation (PubMed:12925201). Involved in lipid raft organization and CD1D localization on thymocytes and antigen-presenting cells, which plays an important role in natural killer T-cell development and activation (By similarity). Plays a role in phagocytosis of apoptotic cells by macrophages (By similarity). Macrophage phagocytosis is stimulated by APOA1 or APOA2, probably by stabilization of ABCA7 (By similarity). Also involved in phagocytic clearance of amyloid-beta by microglia cells and macrophages (By similarity). Further limits amyloid-beta production by playing a role in the regulation of amyloid-beta A4 precursor protein (APP) endocytosis and/or processing (PubMed:26260791). Amyloid-beta is the main component of amyloid plaques found in the brains of Alzheimer patients (PubMed:26260791)