Citramalyl-CoA lyase, mitochondrial (EC 4.1.3.25) ((3S)-malyl-CoA thioesterase) (EC 3.1.2.30) (Beta-methylmalate synthase) (EC 2.3.3.-) (Citrate lyase subunit beta-like protein) (Citrate lyase beta-like) (Malate synthase) (EC 2.3.3.9)
1_MALRL 6_ LRRAA 11_ RGAAA 16_ AALLR 21_ LKASL 26_ AADIP 31_ RLGYS 36_ SSSHH 41_ KYIPR 46_ RAVLY 51_ VPGND 56_ EKKIK 61_ KIPSL 66_ NVDCA 71_ VLDCE 76_ DGVAA 81_ NKKNE 86_ ARLRI 91_ VKTLE 96_ DIDLG 101_ PTEKC 106_ VRVNS 111_ VSSGL 116_ AEEDL 121_ ETLLQ 126_ SRVLP 131_ SSLML 136_ PKVES 141_ PEEIQ 146_ WFADK 151_ FSFHL 156_ KGRKL 161_ EQPMN 166_ LIPFV 171_ ETAMG 176_ LLNFK 181_ AVCEE 186_ TLKVG 191_ PQVGL 196_ FLDAV 201_ VFGGE 206_ DFRAS 211_ IGATS 216_ SKETL 221_ DILYA 226_ RQKIV 231_ VIAKA 236_ FGLQA 241_ IDLVY 246_ IDFRD 251_ GAGLL 256_ RQSRE 261_ GAAMG 266_ FTGKQ 271_ VIHPN 276_ QIAVV 281_ QEQFS 286_ PSPEK 291_ IKWAE 296_ ELIAA 301_ FKEHQ 306_ QLGKG 311_ AFTFQ 316_ GSMID 321_ MPLLK 326_ QAQNT 331_VTLAT
1: Mitochondrial citramalyl-CoA lyase indirectly involved in the vitamin B12 metabolism (PubMed:29056341). Converts citramalyl-CoA into acetyl-CoA and pyruvate in the C5-dicarboxylate catabolism pathway (PubMed:29056341). The C5-dicarboxylate catabolism pathway is required to detoxify itaconate, a vitamin B12-poisoning metabolite (PubMed:29056341). Also acts as a malate synthase in vitro, converting glyoxylate and acetyl-CoA to malate (PubMed:24334609, PubMed:29056341). Also displays malyl-CoA thioesterase activity (PubMed:29056341). Also acts as a beta-methylmalate synthase in vitro, by mediating conversion of glyoxylate and propionyl-CoA to beta-methylmalate (PubMed:24334609, PubMed:29056341). Also has very weak citramalate synthase activity in vitro (PubMed:24334609, PubMed:29056341)