Spartin (Spastic paraplegia 20 protein) (Trans-activated by hepatitis C virus core protein 1)
1_MEQEP 6_ QNGEP 11_ AEIKI 16_ IREAY 21_ KKAFL 26_ FVNKG 31_ LNTDE 36_ LGQKE 41_ EAKNY 46_ YKQGI 51_ GHLLR 56_ GISIS 61_ SKESE 66_ HTGPG 71_ WESAR 76_ QMQQK 81_ MKETL 86_ QNVRT 91_ RLEIL 96_ EKGLA 101_ TSLQN 106_ DLQEV 111_ PKLYP 116_ EFPPK 121_ DMCEK 126_ LPEPQ 131_ SFSSA 136_ PQHAE 141_ VNGNT 146_ STPSA 151_ GAVAA 156_ PASLS 161_ LPSQS 166_ CPAEA 171_ PPAYT 176_ PQAAE 181_ GHYTV 186_ SYGTD 191_ SGEFS 196_ SVGEE 201_ FYRNH 206_ SQPPP 211_ LETLG 216_ LDADE 221_ LILIP 226_ NGVQI 231_ FFVNP 236_ AGEVS 241_ APSYP 246_ GYLRI 251_ VRFLD 256_ NSLDT 261_ VLNRP 266_ PGFLQ 271_ VCDWL 276_ YPLVP 281_ DRSPV 286_ LKCTA 291_ GAYMF 296_ PDTML 301_ QAAGC 306_ FVGVV 311_ LSSEL 316_ PEDDR 321_ ELFED 326_ LLRQM 331_ SDLRL 336_ QANWN 341_ RAEEE 346_ NEFQI 351_ PGRTR 356_ PSSDQ 361_ LKEAS 366_ GTDVK 371_ QLDQG 376_ NKDVR 381_ HKGKR 386_ GKRAK 391_ DTSSE 396_ EVNLS 401_ HIVPC 406_ EPVPE 411_ EKPKE 416_ LPEWS 421_ EKVAH 426_ NILSG 431_ ASWVS 436_ WGLVK 441_ GAEIT 446_ GKAIQ 451_ KGASK 456_ LRERI 461_ QPEEK 466_ PVEVS 471_ PAVTK 476_ GLYIA 481_ KQATG 486_ GAAKV 491_ SQFLV 496_ DGVCT 501_ VANCV 506_ GKELA 511_ PHVKK 516_ HGSKL 521_ VPESL 526_ KKDKD 531_ GKSPL 536_ DGAMV 541_ VAASS 546_ VQGFS 551_ TVWQG 556_ LECAA 561_ KCIVN 566_ NVSAE 571_ TVQTV 576_ RYKYG 581_ YNAGE 586_ ATHHA 591_ VDSAV 596_ NVGVT 601_ AYNIN 606_ NIGIK 611_ AMVKK 616_ TATQT 621_ GHTLL 626_ EDYQI 631_ VDNSQ 636_ RENQE 641_ GAANV 646_ NVRGE 651_ KDEQT 656_ KEVKE 661_AKKKD
1: Lipophagy receptor that plays an important role in lipid droplet (LD) turnover in motor neurons (PubMed:37443287). Localizes to LDs and interacts with components of the autophagy machinery, such as MAP1LC3A/C proteins to deliver LDs to autophagosomes for degradation via lipophagy (PubMed:37443287). Lipid transfer protein required for lipid droplet degradation, including by lipophagy (PubMed:38190532). Can bind and transfer all lipid species found in lipid droplets, from phospholipids to triglycerides and sterol esters but the direction of lipid transfer by spartin and its cargos are unknown (PubMed:38190532). May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis (PubMed:20719964)