Transcription factor ATOH7 (Atonal bHLH transcription factor 7) (Class A basic helix-loop-helix protein 13) (bHLHa13) (Protein atonal homolog 7)
1_MKSCK 6_ PSGPP 11_ AGARV 16_ APPCA 21_ GGTEC 26_ AGTCA 31_ GAGRL 36_ ESAAR 41_ RRLAA 46_ NARER 51_ RRMQG 56_ LNTAF 61_ DRLRR 66_ VVPQW 71_ GQDKK 76_ LSKYE 81_ TLQMA 86_ LSYIM 91_ ALTRI 96_ LAEAE 101_ RFGSE 106_ RDWVG 111_ LHCEH 116_ FGRDH 121_ YLPFP 126_ GAKLP 131_ GESEL 136_ YSQRL 141_ FGFQP 146_EPFQM
1: Transcription factor that binds to DNA at the consensus sequence 5'-CAG[GC]TG-3' (PubMed:31696227). Dimerization with TCF3 isoform E47 may be required in certain situations (PubMed:31696227). Binds to gene promoters and enhancer elements, and thereby regulates a transcriptional program of retinal ganglion cell (RGC) determinant genes (By similarity). Although the exact mechanism is not certain, retinal transcription regulation by ATOH7 has a role in RGC determination and survival, photoreceptor population development, targeting of RGC axons to the optic nerve and development of the retino-hypothalamic tract (By similarity). Binds to its own promoter and enhancer sequences, suggesting autoregulation of ATOH7 transcription (By similarity). Required for retinal circadian rhythm photoentrainment (By similarity). Plays a role in brainstem auditory signaling and binaural processing (By similarity)