Cytochrome P450 4X1 (EC 1.14.14.-) (CYPIVX1)
1_MEFSW 6_ LETRW 11_ ARPFY 16_ LAFVF 21_ CLALG 26_ LLQAI 31_ KLYLR 36_ RQRLL 41_ RDLRP 46_ FPAPP 51_ THWFL 56_ GHQKF 61_ IQDDN 66_ MEKLE 71_ EIIEK 76_ YPRAF 81_ PFWIG 86_ PFQAF 91_ FCIYD 96_ PDYAK 101_ TLLSR 106_ TDPKS 111_ QYLQK 116_ FSPPL 121_ LGKGL 126_ AALDG 131_ PKWFQ 136_ HRRLL 141_ TPGFH 146_ FNILK 151_ AYIEV 156_ MAHSV 161_ KMMLD 166_ KWEKI 171_ CSTQD 176_ TSVEV 181_ YEHIN 186_ SMSLD 191_ IIMKC 196_ AFSKE 201_ TNCQT 206_ NSTHD 211_ PYAKA 216_ IFELS 221_ KIIFH 226_ RLYSL 231_ LYHSD 236_ IIFKL 241_ SPQGY 246_ RFQKL 251_ SRVLN 256_ QYTDT 261_ IIQER 266_ KKSLQ 271_ AGVKQ 276_ DNTPK 281_ RKYQD 286_ FLDIV 291_ LSAKD 296_ ESGSS 301_ FSDID 306_ VHSEV 311_ STFLL 316_ AGHDT 321_ LAASI 326_ SWILY 331_ CLALN 336_ PEHQE 341_ RCREE 346_ VRGIL 351_ GDGSS 356_ ITWDQ 361_ LGEMS 366_ YTTMC 371_ IKETC 376_ RLIPA 381_ VPSIS 386_ RDLSK 391_ PLTFP 396_ DGCTL 401_ PAGIT 406_ VVLSI 411_ WGLHH 416_ NPAVW 421_ KNPKV 426_ FDPLR 431_ FSQEN 436_ SDQRH 441_ PYAYL 446_ PFSAG 451_ SRNCI 456_ GQEFA 461_ MIELK 466_ VTIAL 471_ ILLHF 476_ RVTPD 481_ PTRPL 486_ TFPNH 491_ FILKP 496_ KNGMY 501_LHLKK
1: A cytochrome P450 monooxygenase that selectively catalyzes the epoxidation of the last double bond of the arachidonoyl moiety of anandamide, potentially modulating endocannabinoid signaling. Has no hydroxylase activity toward various fatty acids, steroids and prostaglandins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase)