Regulatory-associated protein of mTOR (Raptor) (p150 target of rapamycin (TOR)-scaffold protein)
1_MESEM 6_ LQSPL 11_ LGLGE 16_ EDEAD 21_ LTDWN 26_ LPLAF 31_ MKKRH 36_ CEKIE 41_ GSKSL 46_ AQSWR 51_ MKDRM 56_ KTVSV 61_ ALVLC 66_ LNVGV 71_ DPPDV 76_ VKTTP 81_ CARLE 86_ CWIDP 91_ LSMGP 96_ QKALE 101_ TIGAN 106_ LQKQY 111_ ENWQP 116_ RARYK 121_ QSLDP 126_ TVDEV 131_ KKLCT 136_ SLRRN 141_ AKEER 146_ VLFHY 151_ NGHGV 156_ PRPTV 161_ NGEVW 166_ VFNKN 171_ YTQYI 176_ PLSIY 181_ DLQTW 186_ MGSPS 191_ IFVYD 196_ CSNAG 201_ LIVKS 206_ FKQFA 211_ LQREQ 216_ ELEVA 221_ AINPN 226_ HPLAQ 231_ MPLPP 236_ SMKNC 241_ IQLAA 246_ CEATE 251_ LLPMI 256_ PDLPA 261_ DLFTS 266_ CLTTP 271_ IKIAL 276_ RWFCM 281_ QKCVS 286_ LVPGV 291_ TLDLI 296_ EKIPG 301_ RLNDR 306_ RTPLG 311_ ELNWI 316_ FTAIT 321_ DTIAW 326_ NVLPR 331_ DLFQK 336_ LFRQD 341_ LLVAS 346_ LFRNF 351_ LLAER 356_ IMRSY 361_ NCTPV 366_ SSPRL 371_ PPTYM 376_ HAMWQ 381_ AWDLA 386_ VDICL 391_ SQLPT 396_ IIEEG 401_ TAFRH 406_ SPFFA 411_ EQLTA 416_ FQVWL 421_ TMGVE 426_ NRNPP 431_ EQLPI 436_ VLQVL 441_ LSQVH 446_ RLRAL 451_ DLLGR 456_ FLDLG 461_ PWAVS 466_ LALSV 471_ GIFPY 476_ VLKLL 481_ QSSAR 486_ ELRPL 491_ LVFIW 496_ AKILA 501_ VDSSC 506_ QADLV 511_ KDNGH 516_ KYFLS 521_ VLADP 526_ YMPAE 531_ HRTMT 536_ AFILA 541_ VIVNS 546_ YHTGQ 551_ EACLQ 556_ GNLIA 561_ ICLEQ 566_ LNDPH 571_ PLLRQ 576_ WVAIC 581_ LGRIW 586_ QNFDS 591_ ARWCG 596_ VRDSA 601_ HEKLY 606_ SLLSD 611_ PIPEV 616_ RCAAV 621_ FALGT 626_ FVGNS 631_ AERTD 636_ HSTTI 641_ DHNVA 646_ MMLAQ 651_ LVSDG 656_ SPMVR 661_ KELVV 666_ ALSHL 671_ VVQYE 676_ SNFCT 681_ VALQF 686_ IEEEK 691_ NYALP 696_ SPATT 701_ EGGSL 706_ TPVRD 711_ SPCTP 716_ RLRSV 721_ SSYGN 726_ IRAVA 731_ TARSL 736_ NKSLQ 741_ NLSLT 746_ EESGG 751_ AVAFS 756_ PGNLS 761_ TSSSA 766_ SSTLG 771_ SPENE 776_ EHILS 781_ FETID 786_ KMRRA 791_ SSYSS 796_ LNSLI 801_ GVSFN 806_ SVYTQ 811_ IWRVL 816_ LHLAA 821_ DPYPE 826_ VSDVA 831_ MKVLN 836_ SIAYK 841_ ATVNA 846_ RPQRV 851_ LDTSS 856_ LTQSA 861_ PASPT 866_ NKGVH 871_ IHQAG 876_ GSPPA 881_ SSTSS 886_ SSLTN 891_ DVAKQ 896_ PVSRD 901_ LPSGR 906_ PGTTG 911_ PAGAQ 916_ YTPHS 921_ HQFPR 926_ TRKMF 931_ DKGPE 936_ QTADD 941_ ADDAA 946_ GHKSF 951_ ISATV 956_ QTGFC 961_ DWSAR 966_ YFAQP 971_ VMKIP 976_ EEHDL 981_ ESQIR 986_ KEREW 991_ RFLRN 996_ SRVRR 1001_ QAQQV 1006_ IQKGI 1011_ TRLDD 1016_ QIFLN 1021_ RNPGV 1026_ PSVVK 1031_ FHPFT 1036_ PCIAV 1041_ ADKDS 1046_ ICFWD 1051_ WEKGE 1056_ KLDYF 1061_ HNGNP 1066_ RYTRV 1071_ TAMEY 1076_ LNGQD 1081_ CSLLL 1086_ TATDD 1091_ GAIRV 1096_ WKNFA 1101_ DLEKN 1106_ PEMVT 1111_ AWQGL 1116_ SDMLP 1121_ TTRGA 1126_ GMVVD 1131_ WEQET 1136_ GLLMS 1141_ SGDVR 1146_ IVRIW 1151_ DTDRE 1156_ MKVQD 1161_ IPTGA 1166_ DSCVT 1171_ SLSCD 1176_ SHRSL 1181_ IVAGL 1186_ GDGSI 1191_ RVYDR 1196_ RMALS 1201_ ECRVM 1206_ TYREH 1211_ TAWVV 1216_ KASLQ 1221_ KRPDG 1226_ HIVSV 1231_ SVNGD 1236_ VRIFD 1241_ PRMPE 1246_ SVNVL 1251_ QIVKG 1256_ LTALD 1261_ IHPQA 1266_ DLIAC 1271_ GSVNQ 1276_ FTAIY 1281_ NSSGE 1286_ LINNI 1291_ KYYDG 1296_ FMGQR 1301_ VGAIS 1306_ CLAFH 1311_ PHWPH 1316_ LAVGS 1321_ NDYYI 1326_SVYSV
1: Component of the mechanistic target of rapamycin complex 1 (mTORC1), an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:26588989, PubMed:32561715, PubMed:37541260). In response to nutrients, growth factors or amino acids, mTORC1 is recruited to the lysosome membrane and promotes protein, lipid and nucleotide synthesis by phosphorylating several substrates, such as ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:26588989, PubMed:37541260). In the same time, it inhibits catabolic pathways by phosphorylating the autophagy initiation components ULK1 and ATG13, as well as transcription factor TFEB, a master regulators of lysosomal biogenesis and autophagy (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:32561715, PubMed:37541260). The mTORC1 complex is inhibited in response to starvation and amino acid depletion (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:37541260). Within the mTORC1 complex, RPTOR acts both as a molecular adapter, which (1) mediates recruitment of mTORC1 to lysosomal membranes via interaction with small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD), and a (2) substrate-specific adapter, which promotes substrate specificity by binding to TOS motif-containing proteins and direct them towards the active site of the MTOR kinase domain for phosphorylation (PubMed:12747827, PubMed:24403073, PubMed:26588989, PubMed:37541260). mTORC1 complex regulates many cellular processes, such as odontoblast and osteoclast differentiation or neuronal transmission (By similarity). mTORC1 complex in excitatory neuronal transmission is required for the prosocial behavior induced by the psychoactive substance lysergic acid diethylamide (LSD) (By similarity)