ORM1-like protein 3
1_MNVGT 6_ AHSEV 11_ NPNTR 16_ VMNSR 21_ GIWLS 26_ YVLAI 31_ GLLHI 36_ VLLSI 41_ PFVSV 46_ PVVWT 51_ LTNLI 56_ HNMGM 61_ YIFLH 66_ TVKGT 71_ PFETP 76_ DQGKA 81_ RLLTH 86_ WEQMD 91_ YGVQF 96_ TASRK 101_ FLTIT 106_ PIVLY 111_ FLTSF 116_ YTKYD 121_ QIHFV 126_ LNTVS 131_ LMSVL 136_ IPKLP 141_ QLHGV 146_RIFGI
1: Plays an essential role in the homeostatic regulation of sphingolipid de novo biosynthesis by modulating the activity of the serine palmitoyltransferase (SPT) in response to ceramide levels (PubMed:20182505, PubMed:30700557, PubMed:37308477). When complexed to SPT, the binding of ceramides to its N-terminus stabilizes a conformation that block SPT substrate entry, hence preventing SPT catalytic activity. Through this mechanism, maintains ceramide levels at sufficient concentrations for the production of complex sphingolipids, but which prevents the accumulation of ceramides to levels that trigger apoptosis (PubMed:37308477)