Leukocyte immunoglobulin-like receptor subfamily A member 2 (CD85 antigen-like family member H) (Immunoglobulin-like transcript 1) (ILT-1) (Leukocyte immunoglobulin-like receptor 7) (LIR-7) (CD antigen CD85h)
1_MTPIL 6_ TVLIC 11_ LGLSL 16_ GPRTH 21_ VQAGH 26_ LPKPT 31_ LWAEP 36_ GSVII 41_ QGSPV 46_ TLRCQ 51_ GSLQA 56_ EEYHL 61_ YRENK 66_ SASWV 71_ RRIQE 76_ PGKNG 81_ QFPIP 86_ SITWE 91_ HAGRY 96_ HCQYY 101_ SHNHS 106_ SEYSD 111_ PLELV 116_ VTGAY 121_ SKPTL 126_ SALPS 131_ PVVTS 136_ GGNVT 141_ LQCVS 146_ QVAFD 151_ GFILC 156_ KEGED 161_ EHPQR 166_ LNSHS 171_ HARGW 176_ SWAIF 181_ SVGPV 186_ SPSRR 191_ WSYRC 196_ YAYDS 201_ NSPYV 206_ WSLPS 211_ DLLEL 216_ LVPGV 221_ SKKPS 226_ LSVQP 231_ GPMVA 236_ PGESL 241_ TLQCV 246_ SDVGY 251_ DRFVL 256_ YKEGE 261_ RDFLQ 266_ RPGWQ 271_ PQAGL 276_ SQANF 281_ TLGPV 286_ SPSHG 291_ GQYRC 296_ YSAHN 301_ LSSEW 306_ SAPSD 311_ PLDIL 316_ ITGQF 321_ YDRPS 326_ LSVQP 331_ VPTVA 336_ PGKNV 341_ TLLCQ 346_ SRGQF 351_ HTFLL 356_ TKEGA 361_ GHPPL 366_ HLRSE 371_ HQAQQ 376_ NQAEF 381_ RMGPV 386_ TSAHV 391_ GTYRC 396_ YSSLS 401_ SNPYL 406_ LSLPS 411_ DPLEL 416_ VVSEA 421_ AETLS 426_ PSQNK 431_ TDSTT 436_ TSLGQ 441_ HPQDY 446_ TVENL 451_ IRMGV 456_ AGLVL 461_ VVLGI 466_ LLFEA 471_ QHSQR 476_SLQDA
1: Part of the innate immune responses against microbial infection (PubMed:12529506, PubMed:27572839). Specifically recognizes a set of N-terminally truncated immunoglobulins that are produced via cleavage by proteases from a range of pathogenic bacteria and fungi, including L.pneumophila, M.hyorhinis, S.pneumoniae, S.aureus and C.albicans (PubMed:27572839). Recognizes epitopes that are in part in the variable region of the immunoglobulin light chains, but requires also the constant region for signaling (PubMed:27572839). Binds to a subset of cleaved IgM, IgG3 and IgG4 molecules, but does not bind cleaved IgA1 (PubMed:27572839). Binding of N-terminally truncated immunoglobulins mediates activation of neutrophils (PubMed:27572839). In monocytes, activation leads to the release of CSF2, CF3, IL6, CXCL8 and CCL3 and down-regulates responses to bacterial lipopolysaccharide (LPS), possibly via down-regulation of TLR4 expression and reduced signaling via TLR4 (PubMed:22479404). In eosinophils, activation by ligand binding leads to the release of RNASE2, IL4 and leukotriene C4 (PubMed:12529506). Does not bind class I MHC antigens (PubMed:19230061)