Vacuolar protein sorting-associated protein 52 homolog (SAC2 suppressor of actin mutations 2-like protein)
1_MAAAA 6_ TMAAA 11_ ARELV 16_ LRAGT 21_ SDMEE 26_ EEGPL 31_ AGGPG 36_ LQEPL 41_ QLGEL 46_ DITSD 51_ EFILD 56_ EVDVH 61_ IQANL 66_ EDELV 71_ KEALK 76_ TGVDL 81_ RHYSK 86_ QVELE 91_ LQQIE 96_ QKSIR 101_ DYIQE 106_ SENIA 111_ SLHNQ 116_ ITACD 121_ AVLER 126_ MEQML 131_ GAFQS 136_ DLSSI 141_ SSEIR 146_ TLQEQ 151_ SGAMN 156_ IRLRN 161_ RQAVR 166_ GKLGE 171_ LVDGL 176_ VVPSA 181_ LVTAI 186_ LEAPV 191_ TEPRF 196_ LEQLQ 201_ ELDAK 206_ AAAVR 211_ EQEAR 216_ GTAAC 221_ ADVRG 226_ VLDRL 231_ RVKAV 236_ TKIRE 241_ FILQK 246_ IYSFR 251_ KPMTN 256_ YQIPQ 261_ TALLK 266_ YRFFY 271_ QFLLG 276_ NERAT 281_ AKEIR 286_ DEYVE 291_ TLSKI 296_ YLSYY 301_ RSYLG 306_ RLMKV 311_ QYEEV 316_ AEKDD 321_ LMGVE 326_ DTAKK 331_ GFFSK 336_ PSLRS 341_ RNTIF 346_ TLGTR 351_ GSVIS 356_ PTELE 361_ APILV 366_ PHTAQ 371_ RGEQR 376_ YPFEA 381_ LFRSQ 386_ HYALL 391_ DNSCR 396_ EYLFI 401_ CEFFV 406_ VSGPA 411_ AHDLF 416_ HAVMG 421_ RTLSM 426_ TLKHL 431_ DSYLA 436_ DCYDA 441_ IAVFL 446_ CIHIV 451_ LRFRN 456_ IAAKR 461_ DVPAL 466_ DRYWE 471_ QVLAL 476_ LWPRF 481_ ELILE 486_ MNVQS 491_ VRSTD 496_ PQRLG 501_ GLDTR 506_ PHYIT 511_ RRYAE 516_ FSSAL 521_ VSINQ 526_ TIPNE 531_ RTMQL 536_ LGQLQ 541_ VEVEN 546_ FVLRV 551_ AAEFS 556_ SRKEQ 561_ LVFLI 566_ NNYDM 571_ MLGVL 576_ MERAA 581_ DDSKE 586_ VESFQ 591_ QLLNA 596_ RTQEF 601_ IEELL 606_ SPPFG 611_ GLVAF 616_ VKEAE 621_ ALIER 626_ GQAER 631_ LRGEE 636_ ARVTQ 641_ LIRGF 646_ GSSWK 651_ SSVES 656_ LSQDV 661_ MRSFT 666_ NFRNG 671_ TSIIQ 676_ GALTQ 681_ LIQLY 686_ HRFHR 691_ VLSQP 696_ QLRAL 701_ PARAE 706_ LINIH 711_ HLMVE 716_LKKHK
1: Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD (PubMed:15878329, PubMed:18367545). Acts as a component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane (PubMed:25799061)