Gamma-aminobutyric acid receptor subunit gamma-1 (GABA(A) receptor subunit gamma-1)
1_MGPLK 6_ AFLFS 11_ PFLLR 16_ SQSRG 21_ VRLVF 26_ LLLTL 31_ HLGNC 36_ VDKAD 41_ DEDDE 46_ DLTVN 51_ KTWVL 56_ APKIH 61_ EGDIT 66_ QILNS 71_ LLQGY 76_ DNKLR 81_ PDIGV 86_ RPTVI 91_ ETDVY 96_ VNSIG 101_ PVDPI 106_ NMEYT 111_ IDIIF 116_ AQTWF 121_ DSRLK 126_ FNSTM 131_ KVLML 136_ NSNMV 141_ GKIWI 146_ PDTFF 151_ RNSRK 156_ SDAHW 161_ ITTPN 166_ RLLRI 171_ WNDGR 176_ VLYTL 181_ RLTIN 186_ AECYL 191_ QLHNF 196_ PMDEH 201_ SCPLE 206_ FSSYG 211_ YPKNE 216_ IEYKW 221_ KKPSV 226_ EVADP 231_ KYWRL 236_ YQFAF 241_ VGLRN 246_ STEIT 251_ HTISG 256_ DYVIM 261_ TIFFD 266_ LSRRM 271_ GYFTI 276_ QTYIP 281_ CILTV 286_ VLSWV 291_ SFWIN 296_ KDAVP 301_ ARTSL 306_ GITTV 311_ LTMTT 316_ LSTIA 321_ RKSLP 326_ KVSYV 331_ TAMDL 336_ FVSVC 341_ FIFVF 346_ AALME 351_ YGTLH 356_ YFTSN 361_ QKGKT 366_ ATKDR 371_ KLKNK 376_ ASMTP 381_ GLHPG 386_ STLIP 391_ MNNIS 396_ VPQED 401_ DYGYQ 406_ CLEGK 411_ DCASF 416_ FCCFE 421_ DCRTG 426_ SWREG 431_ RIHIR 436_ IAKID 441_ SYSRI 446_ FFPTA 451_ FALFN 456_LVYWV
1: Gamma subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:10449790). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:10449790). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (By similarity)