Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 (EC 2.1.1.57) (Cap methyltransferase 1) (Cap1 2'O-ribose methyltransferase 1) (MTr1) (hMTr1) (FtsJ methyltransferase domain-containing protein 2) (Interferon-stimulated gene 95 kDa protein) (ISG95)
1_MKRRT 6_ DPECT 11_ APIKK 16_ QKKRV 21_ AELAL 26_ SLSST 31_ SDDEP 36_ PSSVS 41_ HGAKA 46_ STTSL 51_ SGSDS 56_ ETEGK 61_ QHSSD 66_ SFDDA 71_ FKADS 76_ LVEGT 81_ SSRYS 86_ MYNSV 91_ SQKLM 96_ AKMGF 101_ REGEG 106_ LGKYS 111_ QGRKD 116_ IVEAS 121_ SQKGR 126_ RGLGL 131_ TLRGF 136_ DQELN 141_ VDWRD 146_ EPEPS 151_ ACEQV 156_ SWFPE 161_ CTTEI 166_ PDTQE 171_ MSDWM 176_ VVGKR 181_ KMIIE 186_ DETEF 191_ CGEEL 196_ LHSVL 201_ QCKSV 206_ FDVLD 211_ GEEMR 216_ RARTR 221_ ANPYE 226_ MIRGV 231_ FFLNR 236_ AAMKM 241_ ANMDF 246_ VFDRM 251_ FTNPR 256_ DSYGK 261_ PLVKD 266_ REAEL 271_ LYFAD 276_ VCAGP 281_ GGFSE 286_ YVLWR 291_ KKWHA 296_ KGFGM 301_ TLKGP 306_ NDFKL 311_ EDFYS 316_ ASSEL 321_ FEPYY 326_ GEGGI 331_ DGDGD 336_ ITRPE 341_ NISAF 346_ RNFVL 351_ DNTDR 356_ KGVHF 361_ LMADG 366_ GFSVE 371_ GQENL 376_ QEILS 381_ KQLLL 386_ CQFLM 391_ ALSIV 396_ RTGGH 401_ FICKT 406_ FDLFT 411_ PFSVG 416_ LVYLL 421_ YCCFE 426_ RVCLF 431_ KPITS 436_ RPANS 441_ ERYVV 446_ CKGLK 451_ VGIDD 456_ VRDYL 461_ FAVNI 466_ KLNQL 471_ RNTDS 476_ DVNLV 481_ VPLEV 486_ IKGDH 491_ EFTDY 496_ MIRSN 501_ ESHCS 506_ LQIKA 511_ LAKIH 516_ AFVQD 521_ TTLSE 526_ PRQAE 531_ IRKEC 536_ LRLWG 541_ IPDQA 546_ RVAPS 551_ SSDPK 556_ SKFFE 561_ LIQGT 566_ EIDIF 571_ SYKPT 576_ LLTSK 581_ TLEKI 586_ RPVFD 591_ YRCMV 596_ SGSEQ 601_ KFLIG 606_ LGKSQ 611_ IYTWD 616_ GRQSD 621_ RWIKL 626_ DLKTE 631_ LPRDT 636_ LLSVE 641_ IVHEL 646_ KGEGK 651_ AQRKI 656_ SAIHI 661_ LDVLV 666_ LNGTD 671_ VREQH 676_ FNQRI 681_ QLAEK 686_ FVKAV 691_ SKPSR 696_ PDMNP 701_ IRVKE 706_ VYRLE 711_ EMEKI 716_ FVRLE 721_ MKIIK 726_ GSSGT 731_ PKLSY 736_ TGRDD 741_ RHFVP 746_ MGLYI 751_ VRTVN 756_ EPWTM 761_ GFSKS 766_ FKKKF 771_ FYNKK 776_ TKDST 781_ FDLPA 786_ DSIAP 791_ FHICY 796_ YGRLF 801_ WEWGD 806_ GIRVH 811_ DSQKP 816_ QDQDK 821_ LSKED 826_VLSFI
1: S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway