Basic leucine zipper transcriptional factor ATF-like 2 (B-ATF-2) (Suppressor of AP-1 regulated by IFN) (SARI)
1_MHLCG 6_ GNGLL 11_ TQTDP 16_ KEQQR 21_ QLKKQ 26_ KNRAA 31_ AQRSR 36_ QKHTD 41_ KADAL 46_ HQQHE 51_ SLEKD 56_ NLALR 61_ KEIQS 66_ LQAEL 71_ AWWSR 76_ TLHVH 81_ ERLCP 86_ MDCAS 91_ CSAPG 96_ LLGCW 101_ DQAEG 106_ LLGPG 111_ PQGQH 116_ GCREQ 121_ LELFQ 126_ TPGSC 131_ YPAQP 136_ LSPGP 141_ QPHDS 146_ PSLLQ 151_ CPLPS 156_ LSLGP 161_ AVVAE 166_ PPVQL 171_ SPSPL 176_ LFASH 181_ TGSSL 186_ QGSSS 191_ KLSAL 196_ QPSLT 201_ AQTAP 206_ PQPLE 211_ LEHPT 216_ RGKLG 221_ SSPDN 226_ PSSAL 231_ GLARL 236_ QSREH 241_ KPALS 246_ AATWQ 251_ GLVVD 256_ PSPHP 261_ LLAFP 266_LLSSA
1: AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system. Following infection, participates in the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes (By similarity). Selectively suppresses CCN1 transcription and hence blocks the downstream cell proliferation signals produced by CCN1 and inhibits CCN1-induced anchorage-independent growth and invasion in several cancer types, such as breast cancer, malignant glioma and metastatic melanoma. Possibly acts by interfering with AP-1 binding to CCN1 promoter