Gene name: THEM5

Uniprot entry:

Q8N1Q8

Protein names:

Acyl-coenzyme A thioesterase THEM5 (Acyl-CoA thioesterase THEM5) (EC 3.1.2.2) (Acyl-coenzyme A thioesterase 15) (Thioesterase superfamily member 5)

Protein sequence:

1_MIRRC 6_ FQVAA 11_ RLGHH 16_ RGLLE 21_ APRIL 26_ PRLNP 31_ ASAFG 36_ SSTDS 41_ MFSRF 46_ LPEKT 51_ DLKDY 56_ ALPNA 61_ SWCSD 66_ MLSLY 71_ QEFLE 76_ KTKSS 81_ GWIKL 86_ PSFKS 91_ NRDHI 96_ RGLKL 101_ PSGLA 106_ VSSDK 111_ GDCRI 116_ FTRCI 121_ QVEGQ 126_ GFEYV 131_ IFFQP 136_ TQKKS 141_ VCLFQ 146_ PGSYL 151_ EGPPG 156_ FAHGG 161_ SLAAM 166_ MDETF 171_ SKTAF 176_ LAGEG 181_ LFTLS 186_ LNIRF 191_ KNLIP 196_ VDSLV 201_ VMDVE 206_ LDKIE 211_ DQKLY 216_ MSCIA 221_ HSRDQ 226_ QTVYA 231_ KSSGV 236_ FLQLQ 241_LEEES

Protein annotations

Protein functions:

1: Has acyl-CoA thioesterase activity towards long-chain (C16 and C18) fatty acyl-CoA substrates, with a preference for linoleoyl-CoA and other unsaturated long-chain fatty acid-CoA esters (PubMed:22586271). Plays an important role in mitochondrial fatty acid metabolism, and in remodeling of the mitochondrial lipid cardiolipin (PubMed:22586271). Required for normal mitochondrial function (PubMed:22586271)