Rho guanine nucleotide exchange factor 28 (190 kDa guanine nucleotide exchange factor) (p190-RhoGEF) (p190RhoGEF) (Rho guanine nucleotide exchange factor)
1_MELSC 6_ SEAPL 11_ YGQMM 16_ IYAKF 21_ DKNVY 26_ LPEDA 31_ EFYFT 36_ YDGSH 41_ QRHVM 46_ IAERI 51_ EDNVL 56_ QSSVP 61_ GHGLQ 66_ ETVTV 71_ SVCLC 76_ SEGYS 81_ PVTMG 86_ SGSVT 91_ YVDNM 96_ ACRLA 101_ RLLVT 106_ QANRL 111_ TACSH 116_ QTLLT 121_ PFALT 126_ AGALP 131_ ALDEE 136_ LVLAL 141_ THLEL 146_ PLEWT 151_ VLGSS 156_ SLEVS 161_ SHRES 166_ LLHLA 171_ MRWGL 176_ AKLSQ 181_ FFLCL 186_ PGGVQ 191_ ALALP 196_ NEEGA 201_ TPLDL 206_ ALREG 211_ HSKLV 216_ EDVTN 221_ FQGRW 226_ SPSFS 231_ RVQLS 236_ EEASL 241_ HYIHS 246_ SETLT 251_ LTLNH 256_ TAEHL 261_ LEADI 266_ KLFRK 271_ YFWDR 276_ AFLVK 281_ AFEPE 286_ ARPEE 291_ RTAMP 296_ SSGAE 301_ TEEEI 306_ KNSVS 311_ SRSAA 316_ EKEDI 321_ KRVKS 326_ LVVQH 331_ NEHED 336_ QHSLD 341_ LDRSF 346_ DILKK 351_ SKPPS 356_ TLLAA 361_ GRLSD 366_ MLNGG 371_ DEVYA 376_ NCMVI 381_ DQVGD 386_ LDISY 391_ INIEG 396_ ITATT 401_ SPESR 406_ GCTLW 411_ PQSSK 416_ HTLPT 421_ ETSPS 426_ VYPLS 431_ ENVEG 436_ TAHTE 441_ AQQSF 446_ MSPSS 451_ SCASN 456_ LNLSF 461_ GWHGF 466_ EKEQS 471_ HLKKR 476_ SSSLD 481_ ALDAD 486_ SEGEG 491_ HSEPS 496_ HICYT 501_ PGSQS 506_ SSRTG 511_ IPSGD 516_ ELDSF 521_ ETNTE 526_ PDFNI 531_ SRAES 536_ LPLSS 541_ NLQSK 546_ ESLLS 551_ GVRSR 556_ SYSCS 561_ SPKIS 566_ LGKTR 571_ LVREL 576_ TVCSS 581_ SEEQR 586_ AYSLS 591_ EPPRE 596_ NRIQE 601_ EEWDK 606_ YIIPA 611_ KSESE 616_ KYKVS 621_ RTFSF 626_ LMNRM 631_ TSPRN 636_ KSKTK 641_ SKDAK 646_ DKEKL 651_ NRHQF 656_ APGTF 661_ SGVLQ 666_ CLVCD 671_ KTLLG 676_ KESLQ 681_ CSNCN 686_ ANVHK 691_ GCKDA 696_ APACT 701_ KKFQE 706_ KYNKN 711_ KPQTI 716_ LGNSS 721_ FRDIP 726_ QPGLS 731_ LHPSS 736_ SVPVG 741_ LPTGR 746_ RETVG 751_ QVHPL 756_ SRSVP 761_ GTTLE 766_ SFRRS 771_ ATSLE 776_ SESDH 781_ NSCRS 786_ RSHSD 791_ ELLQS 796_ MGSSP 801_ STESF 806_ IMEDV 811_ VDSSL 816_ WSDLS 821_ SDAQE 826_ FEAES 831_ WSLVV 836_ DPSFC 841_ NRQEK 846_ DVIKR 851_ QDVIF 856_ ELMQT 861_ EMHHI 866_ QTLFI 871_ MSEIF 876_ RKGMK 881_ EELQL 886_ DHSTV 891_ DKIFP 896_ CLDEL 901_ LEIHR 906_ HFFYS 911_ MKERR 916_ QESCA 921_ GSDRN 926_ FVIDR 931_ IGDIL 936_ VQQFS 941_ EENAS 946_ KMKKI 951_ YGEFC 956_ CHHKE 961_ AVNLF 966_ KELQQ 971_ NKKFQ 976_ NFIKL 981_ RNSNL 986_ LARRR 991_ GIPEC 996_ ILLVT 1001_ QRITK 1006_ YPVLV 1011_ ERILQ 1016_ YTKER 1021_ TEEHK 1026_ DLRKA 1031_ LCLIK 1036_ DMIAT 1041_ VDLKV 1046_ NEYEK 1051_ NQKWL 1056_ EILNK 1061_ IENKT 1066_ YTKLK 1071_ NGHVF 1076_ RKQAL 1081_ MSEER 1086_ TLLYD 1091_ GLVYW 1096_ KTATG 1101_ RFKDI 1106_ LALLL 1111_ TDVLL 1116_ FLQEK 1121_ DQKYI 1126_ FAAVD 1131_ QKPSV 1136_ ISLQK 1141_ LIARE 1146_ VANEE 1151_ RGMFL 1156_ ISASS 1161_ AGPEM 1166_ YEIHT 1171_ NSKEE 1176_ RNNWM 1181_ RRIQQ 1186_ AVESC 1191_ PEEKG 1196_ GRTSE 1201_ SDEDK 1206_ RKAEA 1211_ RVAKI 1216_ QQCQE 1221_ ILTNQ 1226_ DQQIC 1231_ AYLEE 1236_ KLHIY 1241_ AELGE 1246_ LSGFE 1251_ DVHLE 1256_ PHLLI 1261_ KPDPG 1266_ EPPQA 1271_ ASLLA 1276_ AALKE 1281_ AESLQ 1286_ VAVKA 1291_ SQMGA 1296_ VSQSC 1301_ EDSCG 1306_ DSVLA 1311_ DTLSS 1316_ HDVPG 1321_ SPTAS 1326_ LVTGG 1331_ REGRG 1336_ CSDVD 1341_ PGIQG 1346_ VVTDL 1351_ AVSDA 1356_ GEKVE 1361_ CRNFP 1366_ GSSQS 1371_ EIIQA 1376_ IQNLT 1381_ RLLYS 1386_ LQAAL 1391_ TIQDS 1396_ HIEIH 1401_ RLVLQ 1406_ QQEGL 1411_ SLGHS 1416_ ILRGG 1421_ PLQDQ 1426_ KSRDA 1431_ DRQHE 1436_ ELANV 1441_ HQLQH 1446_ QLQQE 1451_ QRRWL 1456_ RRCEQ 1461_ QQRAQ 1466_ ATRES 1471_ WLQER 1476_ ERECQ 1481_ SQEEL 1486_ LLRSR 1491_ GELDL 1496_ QLQEY 1501_ QHSLE 1506_ RLREG 1511_ QRLVE 1516_ REQAR 1521_ MRAQQ 1526_ SLLGH 1531_ WKHGR 1536_ QRSLP 1541_ AVLLP 1546_ GGPEV 1551_ MELNR 1556_ SESLC 1561_ HENSF 1566_ FINEA 1571_ LVQMS 1576_ FNTFN 1581_ KLNPS 1586_ VIHQD 1591_ ATYPT 1596_ TQSHS 1601_ DLVRT 1606_ SEHQV 1611_ DLKVD 1616_ PSQPS 1621_ NVSHK 1626_ LWTAA 1631_ GSGHQ 1636_ ILPFH 1641_ ESSKD 1646_ SCKND 1651_ LDTSH 1656_ TESPT 1661_ PHDSN 1666_ SHRPQ 1671_ LQAFI 1676_ TEAKL 1681_ NLPTR 1686_ TMTRQ 1691_ DGETG 1696_DGAKE
1: Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Also functions in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis (By similarity)