Integrator complex subunit 1 (Int1)
1_MNRAK 6_ PTTVR 11_ RPSAA 16_ AKPSG 21_ HPPPG 26_ DFIAL 31_ GSKGQ 36_ ANESK 41_ TASTL 46_ LKPAP 51_ SGLPS 56_ ERKRD 61_ AAAAL 66_ SSASA 71_ LTGLT 76_ KRPKL 81_ SSTPP 86_ LSALG 91_ RLAEA 96_ AVAEK 101_ RAISP 106_ SIKEP 111_ SVVPI 116_ EVLPT 121_ VLLDE 126_ IEAAE 131_ LEGND 136_ DRIEG 141_ VLCGA 146_ VKQLK 151_ VTRAK 156_ PDSTL 161_ YLSLM 166_ YLAKI 171_ KPNIF 176_ ATEGV 181_ IEALC 186_ SLLRR 191_ DASIN 196_ FKAKG 201_ NSLVS 206_ VLACN 211_ LLMAA 216_ YEEDE 221_ NWPEI 226_ FVKVY 231_ IEDSL 236_ GERIW 241_ VDSPH 246_ CKTFV 251_ DNIQT 256_ AFNTR 261_ MPPRS 266_ VLLQG 271_ EAGRV 276_ AGDLG 281_ AGSSP 286_ HPSLT 291_ EEEDS 296_ QTELL 301_ IAEEK 306_ LSPEQ 311_ EGQLM 316_ PRYEE 321_ LAESV 326_ EEYVL 331_ DMLRD 336_ QLNRR 341_ QPIDN 346_ VSRNL 351_ LRLLT 356_ STCGY 361_ KEVRL 366_ LAVQK 371_ LEMWL 376_ QNPKL 381_ TRPAQ 386_ DLLMS 391_ VCMNC 396_ NTHGS 401_ EDMDV 406_ ISHLI 411_ KIRLK 416_ PKVLL 421_ NHFML 426_ CIREL 431_ LSAHK 436_ DNLGT 441_ TIKLV 446_ IFNEL 451_ SSARN 456_ PNNMQ 461_ VLYTA 466_ LQHSS 471_ ELAPK 476_ FLAMV 481_ FQDLL 486_ TNKDD 491_ YLRAS 496_ RALLR 501_ EIIKQ 506_ TKHEI 511_ NFQAF 516_ CLGLM 521_ QERKE 526_ PQYLE 531_ MEFKE 536_ RFVVH 541_ ITDVL 546_ AVSMM 551_ LGITA 556_ QVKEA 561_ GIAWD 566_ KGEKR 571_ NLEVL 576_ RSFQN 581_ QIAAI 586_ QRDAV 591_ WWLHT 596_ VVPSI 601_ SKLAP 606_ KDYVH 611_ CLHKV 616_ LFTEQ 621_ PETYY 626_ KWDNW 631_ PPESD 636_ RNFFL 641_ RLCSE 646_ VPILE 651_ DTLMR 656_ ILVIG 661_ LSREL 666_ PLGPA 671_ DAMEL 676_ ADHLV 681_ KRAAA 686_ VQADD 691_ VEVLK 696_ VGRTQ 701_ LIDAV 706_ LNLCT 711_ YHHPE 716_ NIQLP 721_ PGYQP 726_ PNLAI 731_ STLYW 736_ KAWPL 741_ LLVVA 746_ AFNPE 751_ NIGLA 756_ AWEEY 761_ PTLKM 766_ LMEMV 771_ MTNNY 776_ SYPPC 781_ TLTDE 786_ ETRTE 791_ MLNRE 796_ LQTAQ 801_ REKQE 806_ ILAFE 811_ GHLAA 816_ ASTKQ 821_ TITES 826_ SSLLL 831_ SQLTS 836_ LDPQG 841_ PPRRP 846_ PPHIL 851_ DQVKS 856_ LNQSL 861_ RLGHL 866_ LCRSR 871_ NPDFL 876_ LHIIQ 881_ RQASS 886_ QSMPW 891_ LADLV 896_ QSSEG 901_ SLDVL 906_ PVQCL 911_ CEFLL 916_ HDAVD 921_ DAASG 926_ EEDDE 931_ GESKE 936_ QKAKK 941_ RQRQQ 946_ KQRQL 951_ LGRLQ 956_ DLLLG 961_ PKADE 966_ QTTCE 971_ VLDYF 976_ LRRLG 981_ SSQVA 986_ SRVLA 991_ MKGLS 996_ LVLSE 1001_ GSLRD 1006_ GEEKE 1011_ PPMEE 1016_ DVGDT 1021_ DVLQG 1026_ YQWLL 1031_ RDLPR 1036_ LPLFD 1041_ SVRST 1046_ TALAL 1051_ QQAIH 1056_ METDP 1061_ QTISA 1066_ YLIYL 1071_ SQHTP 1076_ VEEQA 1081_ QHSDL 1086_ ALDVA 1091_ RLVVE 1096_ RSTIM 1101_ SHLFS 1106_ KLSPS 1111_ AASDA 1116_ VLSAL 1121_ LSIFS 1126_ RYVRR 1131_ MRQSK 1136_ EGEEV 1141_ YSWSE 1146_ SQDQV 1151_ FLRWS 1156_ SGETA 1161_ TMHIL 1166_ VVHAM 1171_ VILLT 1176_ LGPPR 1181_ ADDSE 1186_ FQALL 1191_ DIWFP 1196_ EEKPL 1201_ PTAFL 1206_ VDTSE 1211_ EALLL 1216_ PDWLK 1221_ LRMIR 1226_ SEVLR 1231_ LVDAA 1236_ LQDLE 1241_ PQQLL 1246_ LFVQS 1251_ FGIPV 1256_ SSMSK 1261_ LLQFL 1266_ DQAVA 1271_ HDPQT 1276_ LEQNI 1281_ MDKNY 1286_ MAHLV 1291_ EVQHE 1296_ RGASG 1301_ GQTFH 1306_ SLLTA 1311_ SLPPR 1316_ RDSTE 1321_ APKPK 1326_ SSPEQ 1331_ PIGQG 1336_ RIRVG 1341_ TQLRV 1346_ LGPED 1351_ DLAGM 1356_ FLQIF 1361_ PLSPD 1366_ PRWQS 1371_ SSPRP 1376_ VALAL 1381_ QQALG 1386_ QELAR 1391_ VVQGS 1396_ PEVPG 1401_ ITVRV 1406_ LQALA 1411_ TLLSS 1416_ PHGGA 1421_ LVMSM 1426_ HRSHF 1431_ LACPL 1436_ LRQLC 1441_ QYQRC 1446_ VPQDT 1451_ GFSSL 1456_ FLKVL 1461_ LQMLQ 1466_ WLDSP 1471_ GVEGG 1476_ PLRAQ 1481_ LRMLA 1486_ SQASA 1491_ GRRLS 1496_ DVRGG 1501_ LLRLA 1506_ EALAF 1511_ RQDLE 1516_ VVSST 1521_ VRAVI 1526_ ATLRS 1531_ GEQCS 1536_ VEPDL 1541_ ISKVL 1546_ QGLIE 1551_ VRSPH 1556_ LEELL 1561_ TAFFS 1566_ ATADA 1571_ ASPFP 1576_ ACKPV 1581_ VVVSS 1586_ LLLQE 1591_ EEPLA 1596_ GGKPG 1601_ ADGGS 1606_ LEAVR 1611_ LGPSS 1616_ GLLVD 1621_ WLEML 1626_ DPEVV 1631_ SSCPD 1636_ LQLRL 1641_ LFSRR 1646_ KGKGQ 1651_ AQVPS 1656_ FRPYL 1661_ LTLFT 1666_ HQSSW 1671_ PTLHQ 1676_ CIRVL 1681_ LGKSR 1686_ EQRFD 1691_ PSASL 1696_ DFLWA 1701_ CIHVP 1706_ RIWQG 1711_ RDQRT 1716_ PQKRR 1721_ EELVL 1726_ RVQGP 1731_ ELISL 1736_ VELIL 1741_ AEAET 1746_ RSQDG 1751_ DTAAC 1756_ SLIQA 1761_ RLPLL 1766_ LSCCC 1771_ GDDES 1776_ VRKVT 1781_ EHLSG 1786_ CIQQW 1791_ GDSVL 1796_ GRRCR 1801_ DLLLQ 1806_ LYLQR 1811_ PELRV 1816_ PVPEV 1821_ LLHSE 1826_ GAASS 1831_ SVCKL 1836_ DGLIH 1841_ RFITL 1846_ LADTS 1851_ DSRAL 1856_ ENRGA 1861_ DASMA 1866_ CRKLA 1871_ VAHPL 1876_ LLLRH 1881_ LPMIA 1886_ ALLHG 1891_ RTHLN 1896_ FQEFR 1901_ QQNHL 1906_ SCFLH 1911_ VLGLL 1916_ ELLQP 1921_ HVFRS 1926_ EHQGA 1931_ LWDCL 1936_ LSFIR 1941_ LLLNY 1946_ RKSSR 1951_ HLAAF 1956_ INKFV 1961_ QFIHK 1966_ YITYN 1971_ APAAI 1976_ SFLQK 1981_ HADPL 1986_ HDLSF 1991_ DNSDL 1996_ VMLKS 2001_ LLAGL 2006_ SLPSR 2011_ DDRTD 2016_ RGLDE 2021_ EGEEE 2026_ SSAGS 2031_ LPLVS 2036_ VSLFT 2041_ PLTAA 2046_ EMAPY 2051_ MKRLS 2056_ RGQTV 2061_ EDLLE 2066_ VLSDI 2071_ DEMSR 2076_ RRPEI 2081_ LSFFS 2086_ TNLQR 2091_ LMSSA 2096_ EECCR 2101_ NLAFS 2106_ LALRS 2111_ MQNSP 2116_ SIAAA 2121_ FLPTF 2126_ MYCLG 2131_ SQDFE 2136_ VVQTA 2141_ LRNLP 2146_ EYALL 2151_ CQEHA 2156_ AVLLH 2161_ RAFLV 2166_ GMYGQ 2171_ MDPSA 2176_ QISEA 2181_LRILH
1: Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:25201415, PubMed:33243860, PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:33243860). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144, PubMed:26308897, PubMed:30737432). Within the integrator complex, INTS1 is involved in the post-termination step: INTS1 displaces INTS3 and the SOSS factors, allowing the integrator complex to return to the closed conformation, ready to bind to the paused elongation complex for another termination cycle (PubMed:38570683). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267)