Nesprin-4 (KASH domain-containing protein 4) (KASH4) (Nuclear envelope spectrin repeat protein 4)
1_MALSL 6_ PLGPR 11_ LGSEP 16_ LNHPP 21_ GAPRE 26_ ADIVG 31_ CTVCP 36_ ASGEE 41_ STSPE 46_ QAQTL 51_ GQDSL 56_ GPPEH 61_ FQGGP 66_ RGNEP 71_ AAHPP 76_ RWSTP 81_ SSYED 86_ PAGGK 91_ HCEHP 96_ ISGLE 101_ VLEAE 106_ QNSLH 111_ LCLLG 116_ LGRRL 121_ QDLEQ 126_ GLGHW 131_ ALAQS 136_ GMVQL 141_ QALQV 146_ DLRGA 151_ AERVE 156_ ALLAF 161_ GEGLA 166_ QRSEP 171_ RAWAA 176_ LEQIL 181_ RALGA 186_ YRDSI 191_ FRRLW 196_ QLQAQ 201_ LVSYS 206_ LVFEE 211_ ANTLD 216_ QDLEV 221_ EGDSD 226_ WPGPG 231_ GVWGP 236_ WAPSS 241_ LPTST 246_ ELEWD 251_ PAGDI 256_ GGLGP 261_ LGQKT 266_ ARTLG 271_ VPCEL 276_ CGQRG 281_ PQGRG 286_ QGLEE 291_ ADTSH 296_ SRQDM 301_ LESGL 306_ GHQKR 311_ LARHQ 316_ RHSLL 321_ RKPQD 326_ KKRQA 331_ SPHLQ 336_ DVRLE 341_ GNPGA 346_ PDPAS 351_ RQPLT 356_ FLLIL 361_ FLLFL 366_ LLVGA 371_ MFLLP 376_ ASGGP 381_ CCSHA 386_ RIPRT 391_ PYLVL 396_SYVNG
1: As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (By similarity). Behaves as a kinesin cargo, providing a functional binding site for kinesin-1 at the nuclear envelope. Hence may contribute to the establishment of secretory epithelial morphology by promoting kinesin-dependent apical migration of the centrosome and Golgi apparatus and basal localization of the nucleus (By similarity)