Histone H2B type 3-B (H2B type 12) (H2B.U histone 1)
1_MPDPS 6_ KSAPA 11_ PKKGS 16_ KKAVT 21_ KAQKK 26_ DGKKR 31_ KRGRK 36_ ESYSI 41_ YVYKV 46_ LKQVH 51_ PDTGI 56_ SSKAM 61_ GIMNS 66_ FVNDI 71_ FERIA 76_ SEASR 81_ LAHYN 86_ KRSTI 91_ TSREV 96_ QTAVR 101_ LLLPG 106_ ELAKH 111_ AVSEG 116_ TKAVT 121_KYTSS
1: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling