Rho GTPase-activating protein 24 (Filamin-A-associated RhoGAP) (FilGAP) (RAC1- and CDC42-specific GTPase-activating protein of 72 kDa) (RC-GAP72) (Rho-type GTPase-activating protein 24) (RhoGAP of 73 kDa) (Sarcoma antigen NY-SAR-88) (p73RhoGAP)
1_MEENN 6_ DSTEN 11_ PQQGQ 16_ GRQNA 21_ IKCGW 26_ LRKQG 31_ GFVKT 36_ WHTRW 41_ FVLKG 46_ DQLYY 51_ FKDED 56_ ETKPL 61_ GTIFL 66_ PGNKV 71_ SEHPC 76_ NEENP 81_ GKFLF 86_ EVVPG 91_ GDRDR 96_ MTANH 101_ ESYLL 106_ MASTQ 111_ NDMED 116_ WVKSI 121_ RRVIW 126_ GPFGG 131_ GIFGQ 136_ KLEDT 141_ VRYEK 146_ RYGNR 151_ LAPML 156_ VEQCV 161_ DFIRQ 166_ RGLKE 171_ EGLFR 176_ LPGQA 181_ NLVKE 186_ LQDAF 191_ DCGEK 196_ PSFDS 201_ NTDVH 206_ TVASL 211_ LKLYL 216_ RELPE 221_ PVIPY 226_ AKYED 231_ FLSCA 236_ KLLSK 241_ EEEAG 246_ VKELA 251_ KQVKS 256_ LPVVN 261_ YNLLK 266_ YICRF 271_ LDEVQ 276_ SYSGV 281_ NKMSV 286_ QNLAT 291_ VFGPN 296_ ILRPK 301_ VEDPL 306_ TIMEG 311_ TVVVQ 316_ QLMSV 321_ MISKH 326_ DCLFP 331_ KDAEL 336_ QSKPQ 341_ DGVSN 346_ NNEIQ 351_ KKATM 356_ GQLQN 361_ KENNN 366_ TKDSP 371_ SRQCS 376_ WDKSE 381_ SPQRS 386_ SMNNG 391_ SPTAL 396_ SGSKT 401_ NSPKN 406_ SVHKL 411_ DVSRS 416_ PPLMV 421_ KKNPA 426_ FNKGS 431_ GIVTN 436_ GSFSS 441_ SNAEG 446_ LEKTQ 451_ TTPNG 456_ SLQAR 461_ RSSSL 466_ KVSGT 471_ KMGTH 476_ SVQNG 481_ TVRMG 486_ ILNSD 491_ TLGNP 496_ TNVRN 501_ MSWLP 506_ NGYVT 511_ LRDNK 516_ QKEQA 521_ GELGQ 526_ HNRLS 531_ TYDNV 536_ HQQFS 541_ MMNLD 546_ DKQSI 551_ DSATW 556_ STSSC 561_ EISLP 566_ ENSNS 571_ CRSST 576_ TTCPE 581_ QDFFG 586_ GNFED 591_ PVLDG 596_ PPQDD 601_ LSHPR 606_ DYESK 611_ SDHRS 616_ VGGRS 621_ SRATS 626_ SSDNS 631_ ETFVG 636_ NSSSN 641_ HSALH 646_ SLVSS 651_ LKQEM 656_ TKQKI 661_ EYESR 666_ IKSLE 671_ QRNLT 676_ LETEM 681_ MSLHD 686_ ELDQE 691_ RKKFT 696_ MIEIK 701_ MRNAE 706_ RAKED 711_ AEKRN 716_ DMLQK 721_ EMEQF 726_ FSTFG 731_ ELTVE 736_ PRRTE 741_RGNTI
1: Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis